The OAT (organic anion transporter) family member URAT1, which is restricted to the apical (brush border) membrane of renal proximal tubular cells, was first cloned from the human kidney. By mediating uric acid reabsorption, URAT1 controls blood uric acid concentrations. Toxicological effects may result from URAT1 activity impairment brought on by polymorphisms or drug-drug interactions. URAT1 is a protein that is found in the kidney and is involved in the reabsorption and excretion of uric acid, organic acids, drugs, and their metabolites. It is distributed along the renal tubular cell membrane. In exchange for dicarboxylic acid, uric acid is taken up by OAT1 and OAT3 from the blood and reabsorbed into renal tubular cells by URAT1.URAT1 and OAT4 facilitate uric acid uptake into renal tubular cells in exchange for organic anions like lactic acid and nicotinic acid in the renal tubule. This electroneutral exchange can be trans-stimulated by lactate gradients carried by sodium-monocarboxylate transporters as well as Cl- gradients. URAT1 is found throughout the surface of the salivary glands, including the ductal and acinar cells, suggesting that it plays a part in the transport of uric acid and other organic acids throughout the entire salivary gland.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V100029 | Darbinuradum | 1877347-38-0 | Darbinurad is a urate transporter inhibitor. |
|
V100773 | Epaminurad hydrochloride | 1198153-46-6 | Epaminurad (UR-1102) hydrochloride is an orally active and selective URAT1 (uric acid transporter 1) inhibitor with Ki of 0.057 μM. |
|
V85514 | HC-1310 | 2101230-88-8 | |
|
V137427 | HNW005 | HNW005 is a dual inhibitor of NLRP3 inflammasome and uric acid transporter 1 (URAT1). | |
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V98190 | hURAT1 inhibitor 1 | hURAT1 inhibitor 1 (compound 27b) is an isomaltine-based, orally active hURAT1/GLUT9 dual inhibitor with IC50 of 0.16 μM and 4.47 μM, respectively. | |
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V137641 | hURAT1 inhibitor 2 | 1402818-99-8 | hURAT1 inhibitor 2 is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 value of 18 nM. |
|
V137711 | HYJ-2 | HYJ-2 is a URAT1 inhibitor that has the effect of lowering uric acid. | |
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V41641 | KPH2f | 2760615-09-4 | KPH2f is a novel, orally bioactive and potent dual URAT1/GLUT9 inhibitor with the potential to be used an anti-hyperuricemic agent for gout treatment. |
|
V74254 | Lingdolinurad | 2088176-96-7 | Lingdolinurad is a uric acid transporter inhibitor that targets hURAT1. |
|
V74247 | Ruzinurad (HR011303; SHR4640) | 1638327-48-6 | Ruzinurad (HR011303) is a selective URATl inhibitor (WO2020088641, compound I). |
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V87250 | URAT1 inhibitor 10 | 3012586-38-5 | URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor (IC50 = 0.052 μM). |
|
V104483 | URAT1 inhibitor 11 | 2416416-13-0 | URAT1 inhibitor 11 (Compound 7) is a URAT1 inhibitor with IC50 of 0.18 μM. |
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V146785 | URAT1 inhibitor 13 | 2816864-54-5 | URAT1 inhibitor 13 is a potent URAT1 inhibitor. |
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V74248 | URAT1 inhibitor 2 | 2803951-18-8 | URAT1 inhibitor 2 is an orally bioactive URAT1 and CYP isozyme inhibitor, with IC50s of 1.36 μM, 16.97 μM, and 5.22 μM for URAT1-mediated 14C-UA absorption, CYP1A2, and CYP2C9, respectively. |
|
V74249 | URAT1 inhibitor 3 | 2850331-30-3 | URAT1 inhibitor 3 is an orally bioavailable and selective URAT1 inhibitor (antagonist) with IC50 of 0.8 nM. |
|
V74198 | URAT1 inhibitor 4 | 2700292-02-8 | URAT1 inhibitor 4 is an analogue of Lesinurad and an orally bioactive URAT1 inhibitor (antagonist) with IC50 of 7.56 μM. |
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V74251 | URAT1 inhibitor 5 | 2102670-94-8 | URAT1 inhibitor 5 (compound 16) is a potent URAT1 inhibitor. |
|
V74246 | URAT1 inhibitor 6 | 2244807-49-4 | URAT1 inhibitor 6 (Compound 1h) is a potent inhibitor of URAT1 (IC50 for hURAT1 is 35 nM). |
|
V74250 | URAT1 inhibitor 8 | 1632005-33-4 | URAT1 inhibitor 8 (example 247) is a potent URAT1 inhibitor (antagonist) with IC50 of 0.001 μM. |
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V84527 | URAT1 inhibitor 9 | 2251727-90-7 |
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