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Transthyretin (TTR)

Transthyretin (TTR)

A tetrameric protein called transthyretin (TTR), formerly known as thyroxine-binding prealbumin, transports hormones in the brain and plasma. Thyroid hormones and vitamin A are more easily transported in the blood and cerebrospinal fluid thanks to the complex it forms with retinol-binding protein (RBP). TTR has a negative correlation with inflammation and a positive indicator of nutrition status. TTR functions as a neuroprotective and anti-oxidative stress agent. Mutations, oxidative modifications, aging, proteolysis, and metal cations, such as Ca2+, all cause the TTR structure to become unstable. Senile and familial amyloidopathies are caused by amyloid deposits created by destabilized TTR molecules.

Transthyretin (TTR) related products

Structure Cat No. Product Name CAS No. Product Description
Acoramidis hydrochloride (AG10 hydrochloride) V70111 Acoramidis hydrochloride (AG10 hydrochloride) 2242751-53-5 Acoramidis (AG10) HCl is an orally bioactive, selective stabilizer of transthyretin (TTR (transthyretin)), effective against both wild-type and V1221 mutants.
Cliramitug V131921 Cliramitug 2965214-50-8 Cliramitug is a monoclonal antibody that targets human transthyretin (TTR).
Coramitug V132076 Coramitug 2626841-92-5 Coramitug is an anti-TTR human IgG1κ monoclonal antibody.
Eplontersen sodium V70112 Eplontersen sodium 2131025-75-5 Eplontersen sodium is a triantennary, N-acetylgalactosamine (GalNAc3)-conjugated antisense oligonucleotide that targets transthyretin TTR mRNA and inhibits variant and wild-type TTR production.
Eplontersen sodium scrambled negative control V135180 Eplontersen sodium scrambled negative control The Eplontersen sodium scrambled negative control is a negative control for Eplontersen sodium with a scrambled sequence.
Guanidino-G-Clamp-PNA V137000 Guanidino-G-Clamp-PNA 476667-31-9 Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencing agent.
Human prealbumin V115137 Human prealbumin Human prealbumin (human transthyretin) is a homotetrameric protein mainly synthesized by the liver and choroid plexus.
Inotersen sodium (ISIS-420915 sodium) V70110 Inotersen sodium (ISIS-420915 sodium) 1432726-13-0 Inotersen (ISIS-420915) sodium is a 2'-O-methoxyethyl modified antisense oligonucleotide.
Inotersen sodium scrambled negative control V137973 Inotersen sodium scrambled negative control The Inotersen sodium scrambled negative control is a negative control for Inotersen sodium with a scrambled sequence.
NI-301 V141326 NI-301 NI-301 is a human monoclonal antibody (mAb) that targets transthyretin/TTR.
Nucresiran V116868 Nucresiran Nucresiran is an siRNA that can inhibit the synthesis of wild-type and variant transthyretin protein mRNA in the liver.
Nucresiran sodium V116821 Nucresiran sodium Nucresiran sodium is a siRNA that can inhibit the synthesis of wild-type and variant transthyretin protein mRNA in the liver.
Nucresiran sodium scrambled negative control V141707 Nucresiran sodium scrambled negative control The Nucresiran sodium scrambled negative control is a negative control with the sequence of Nucresiran sodium scrambled.
Patisiran sodium V70106 Patisiran sodium 1386913-72-9 Patisiran sodium is a double-stranded small interfering RNA that targets sequences within the Transthyretin (TTR) messenger RNA.
PITB V81150 PITB PITB is a selective, orally bioactive inhibitor of transthyretin (TTR) aggregation.
Tafamidis V4862 Tafamidis 594839-88-0 Tafamidis (also known as Fx-1006 or PF-06291826; Vyndaqel and Vyndamax), a potent and selective transthyretin (TTR)stabilizer, is a medication approved for use in delaying disease progression in adults with certain forms of transthyretin amyloidosis.
Transthyretin-IN-2 V87853 Transthyretin-IN-2 4664-62-4 Transthyretin-IN-2 (Compound 36) is a transthyretin (TTR) amyloidosis inhibitor with IC50 and pIC50 values of 1.31 μM and 5.88 μM, respectively.
Transthyretin-IN-3 V87852 Transthyretin-IN-3 3008535-20-1 Transthyretin-IN-3 (compound 6) is a designed benzofuran analog.
Transthyretin-IN-4 V146376 Transthyretin-IN-4 2765296-93-1 Transthyretin-IN-4 is a bivalent inhibitor of transthyretin (TTR) amyloidosis (bIC50: 0.09 µM, pIC50: 1.4 µM).
TTR stabilizer 1 V97925 TTR stabilizer 1 2778162-15-3 TTR stabilizer 1 (Compound 1) is a stabilizer of transthyretin (TTR) with an EC50 value of 0.031 μM.
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