Integral membrane proteins called serotonin transporters (SERTs) move serotonin from synaptic spaces into presynaptic neurons. Serotonin's function is effectively terminated and neuronal transmission is stopped by SERTs, which reabsorb it in the synaptic cleft. Reuptake of serotonin is essential for avoiding nerve overstimulation.
By delivering 5-hydroxytryptamine (5HT) to neurons and glial cells, the serotonin transporter (SERT) controls the extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain. Drugs used to treat emotional disorders, such as depression, primarily target the human SERT (hSERT). The bacterial leucine transporter (LeuT), for which a high resolution crystal structure is now available, is a member of the solute carrier 6 family, which also includes hSERT.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70017 | Edivoxetine hydrochloride (LY 2216684 hydrochloride) | 1194374-05-4 | Edivoxetine (HCl) is a potent and selective norepinephrine reuptake inhibitor (NERI) used in depression or attention-deficit/hyperactivity disorder. |
|
V20710 | Escitalopram | 128196-01-0 | Escitalopram (Lu10171;Cipralex; Seroplex;Lu-10171; Citalopram;Lexapro; Cytalopram), the S-isomer/enantiomer of citalopram, is an approved antidepressant drug acting as a selective serotonin (5-HT) reuptake inhibitor (SSRI) with a Ki of 0.89 nM. |
|
V70012 | Escitalopram-d6 oxalate (escitalopram d6 oxalate) | 1217733-09-9 | Escitalopram-d6 (oxalate) is the deuterated form of Escitalopram oxalate. |
|
V79931 | Fluvoxamine-d4 maleate (DU-23000-d4 (maleate)) | Fluvoxamine-d4 (maleate) is the deuterium labelled form of Fluvoxamine maleate. | |
|
V12313 | Levomilnacipran HCl (F2695; Fetzima) | 175131-60-9 | Levomilnacipran (F2695; Fetzima), the S-enantiomer ofMilnacipran, is an antidepressant approved for the treatment of major depressive disorder in the United States. |
|
V2399 | Milnacipran HCl | 101152-94-7 | Milnacipran HCl, a medication used in the clinical treatment of fibromyalgia,is a potent inhibitor of both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
|
V70009 | Nardoguaianone J (10-epi-Nardoguaianone K) | 443128-64-1 | Nardoguaianone J, a guaiac compound, is extracted from the roots of Nardostachys chinensis. |
|
V70028 | Nardosinonediol (Tetrahydronardosinon) | 20489-11-6 | Nardosinonediol (Tetrahydronardosinon) is a serotonin transporter (SERT) inhibitor. |
|
V70007 | rel-Sertraline-d3 hydrochloride (sertraline d3 hydrochloride (hydrochloride)) | 1330180-66-9 | rel-Sertraline-d3 ( HCl) is the deuterated form of Sertraline HCl. |
|
V70002 | SERT-IN-2 | 2055228-33-4 | SERT-IN-2 is a potent SERT inhibitor (IC50=0.58 nM) with antidepressant activity. |
|
V27970 | Venlafaxine (Wy 45030) | 93413-69-5 | Venlafaxine free base (Wy-45030; Wy45030; Effexor, Lanvexin, Viepax and Trevilor) is a marketed and arylalkanolamine-based antidepressant acting as an serotonin-norepinephrine reuptake inhibitor (SNRI). |
|
V70015 | Venlafaxine-d10 hydrochloride (venlafaxine d10 hydrochloride) | 1216539-56-8 | Venlafaxine-d10 ( HCl) is the deuterium labelled form of Venlafaxine HCl. |
|
V70001 | Venlafaxine-d6 hydrochloride (Wy 45030-d6 (hydrochloride)) | 1062606-12-5 | Venlafaxine-d6 ( HCl) is the deuterated form of Venlafaxine HCl. |
|
V70000 | ZZL-7 | 99141-91-0 | ZZL-7 is a fast-acting antidepressant. |
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