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Monoamine Oxidase

Monoamine Oxidase

A family of enzymes known as monoamine oxidases (MAO) catalyzes the oxidation of monoamines. In the majority of the body's cell types, they are discovered bound to the mitochondria's outer membrane. They are a member of the flavin-containing amine oxidoreductase protein family. The oxidative deamination of monoamines is catalyzed by monoamine oxidases. By using oxygen to remove an amine group from a molecule, the resulting aldehyde and ammonia are produced.Flavoproteins are monoamine oxidases because they have the cofactor FAD covalently bound to them. MAO dysfunction is thought to be the cause of a number of psychiatric and neurological disorders due to the critical part MAOs play in the inactivation of neurotransmitters. While MAO-B inhibitors are used alone or in combination to treat Alzheimer's and Parkinson's diseases, MAO-A inhibitors have antidepressant and antianxiety properties.

Monoamine Oxidase related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Cinchonaminone V70662 (+)-Cinchonaminone 60305-15-9 (+)-Cinchonaminone displays MAO (monoamine oxidase) inhibitory activity.
(1S,2R)-Tranylcypromine-d5 hydrochloride V87820 (1S,2R)-Tranylcypromine-d5 hydrochloride (1S,2R)-Tranylcypromine-d5 (hydrochloride) is the deuterated derivative of Tranylcypromine hydrochloride.
(E)-CHBO4 V106809 (E)-CHBO4 126473-61-8 (E)-CHBO4 is a MAO-B inhibitor with IC50 of 0.023 μM, which can be used to treat Parkinson's disease.
(R)-Safinamide V87826 (R)-Safinamide 174756-44-6 (R)-Safinamide is the enantiomer of safinamide and can inhibit MAO-B with an IC50 value of 0.45 μM.
(±)-Amiflamine (FLA 336) V70685 (±)-Amiflamine (FLA 336) 77502-96-6 (±)-Amiflamine (FLA 336) is a potent MAO (monoamine oxidase) (MAO-A) with pIC50 of 5.57.
1,4-Naphthoquinone-d6 V70672 1,4-Naphthoquinone-d6 26473-08-5 1,4-Naphthoquinone-d6 is the deuterated form of 1,4-Naphthoquinone.
1-Methyl-2-undecyl-4(1H)-quinolone V70693 1-Methyl-2-undecyl-4(1H)-quinolone 59443-02-6 1-Methyl-2-undecyl-4(1H)-quinolone is a potent irreversible and selective monoamine oxidase type B (MAO-B) inhibitor.
2-APB hydrochloride V107520 2-APB hydrochloride 3710-48-3 2-APB is an analog of 6-APB, a benzofuran derivative, and a psychoactive substance.
4-Hydroxyderricin V70643 4-Hydroxyderricin 55912-03-3 4-Hydroxyderricin is one of the main active ingredients of Ashitaba and is a potent and specific MAO-B (monoamine oxidase inhibitor) inhibitor (antagonist) with IC50 of 3.43 μM.
5-(2-Aminopropyl)indole V105570 5-(2-Aminopropyl)indole 3784-30-3 5-(2-Aminopropyl)indole An orally active psychoactive substance with monoamine oxidase (MAO) inhibitory and long-lasting stimulatory properties.
5-LOX-IN-7 V101924 5-LOX-IN-7 1272519-89-7 LOX-IN-7 (Compound 18) is a potent LOX inhibitor.
6,7-Dimethylisatin V102297 6,7-Dimethylisatin 20205-43-0 6,7-Dimethylindigo (compound 1l), an indigo analog, is also a potent MAO inhibitor with IC50 values of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively.
6-Acetonyl-N-methyldihydrodecarine V70678 6-Acetonyl-N-methyldihydrodecarine 1253740-09-8 6-Acetonyl-N-methyldihydrodecarine is an alkaloid extracted from the roots of Zanthoxylum rigidum and is an inhibitor (blocker/antagonist) of MAO (monoamine oxidase).
A2AAR/hMAO-B-IN-1 V102753 A2AAR/hMAO-B-IN-1 1439488-21-7 A2AAR/hMAO-B-IN-1 (Compound 17) is a non-xanthine dual-target inhibitor targeting A2A adenosine receptor (A2AAR) (IC50: 34.9 nM) and MAO-B (Ki: 39.5 nM, human).
Acacetin 7-O-(6-O-malonylglucoside) V90920 Acacetin 7-O-(6-O-malonylglucoside) 155049-92-6 Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase (MAO) inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values of 2.34 and 1.87 μM, respectively.
Aminoacetone hydrochloride V70640 Aminoacetone hydrochloride 7737-17-9 Aminoacetone HCl is the simplest single peptide.
Antioxidant agent-13 V78050 Antioxidant agent-13 2966778-87-8 Antioxidant agent-13 (Compound 5f) is an antioxidant.
Bazinaprine V87818 Bazinaprine 94011-82-2 Bazinaprine (SR 95191) is a derivative of minaprine and an orally active monoamine oxidase type A (MAO) inhibitor.
C175-0062 V103853 C175-0062 686736-69-6 C175-0062 is a monoamine oxidase B (MAO-B) inhibitor.
ChEs/MAOs-IN-1 V85269 ChEs/MAOs-IN-1
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