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Beta Amyloid

Beta Amyloid

As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.

Beta Amyloid related products

Structure Cat No. Product Name CAS No. Product Description
2,3-Dehydrosilybin A V71438 2,3-Dehydrosilybin A 25166-14-7 2,3-Dehydrosilybin A is a longevity-promoting and anti-aggregation compound.
2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 V71371 2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 1331662-16-8 2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 is deuterated labeled 2-Hydroxy-5-(phenyldiazenyl)benzoic acid.
2002-G12 V104737 2002-G12 313666-93-2 2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%.
4-Sulfocalix[4]arene V111853 4-Sulfocalix[4]arene 112269-92-8 4-Sulfocalix[4]arene (p-sulfonocalix[n]arene) is an amyloid β42 (amyloid β42) binder with a Kd value of 5.39 M.
5-FAM-β-Amyloid (1-42), human TFA (5-FAM-Amyloid β-peptide (1-42) (human) TFA) V77650 5-FAM-β-Amyloid (1-42), human TFA (5-FAM-Amyloid β-peptide (1-42) (human) TFA) 5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) TFA is a 5-FAM-labeled β-Amyloid (1-42), human (TFA).
5-FAM-β-Amyloid (1-42), human Tris (5-FAM-Amyloid β-peptide (1-42) (human) Tris) V86199 5-FAM-β-Amyloid (1-42), human Tris (5-FAM-Amyloid β-peptide (1-42) (human) Tris)
6′-Methyl paeonol V83543 6′-Methyl paeonol 6540-66-5
7-Deoxy-trans-dihydronarciclasine V71443 7-Deoxy-trans-dihydronarciclasine 145987-74-2 7-Deoxy-trans-dihydronarciclasine is an alkaloid and an inhibitor (blocker/antagonist) of tobacco mosaic virus (TMV) (IC50= 1.80 μM).
[Ala28]-β Amyloid(25-35) (β(25-35)KA) V71439 [Ala28]-β Amyloid(25-35) (β(25-35)KA) 173993-86-7 [Ala28]-β Amyloid(25-35) (β(25-35)KA) is an electroneutral mutant peptide of Aβ(25-35) that accelerates the aggregation of firefly luciferase.
[Ala28]-β Amyloid(25-35) TFA V114718 [Ala28]-β Amyloid(25-35) TFA [Ala28]-β amyloid(25-35) (β(25-35)KA) TFA is an electronegative mutant peptide of Aβ(25-35) that can accelerate the aggregation of firefly luciferase.
[Arg6]-β-Amyloid (1-40), england mutation V71378 [Arg6]-β-Amyloid (1-40), england mutation 1802084-26-9 [Arg6]-β-Amyloid (1-40), england mutation is a biologically active peptide.
[Arg6]-β-Amyloid (1-42), england mutation V77472 [Arg6]-β-Amyloid (1-42), england mutation [Arg6]-β-Amyloid (1-42), england mutation is a biologically active peptide.
[Asn23] β-Amyloid (1-40), Iowa mutation V71392 [Asn23] β-Amyloid (1-40), Iowa mutation 374796-72-2 [Asn23] β-Amyloid (1-40), Iowa mutation is a biologically active peptide.
[Asn23]-beta-Amyloid (1-42), iowa mutation V77473 [Asn23]-beta-Amyloid (1-42), iowa mutation [Asn23]-beta-Amyloid (1-42), iowa mutation is a biologically active peptide.
[D-Ser14]-Humanin V92286 [D-Ser14]-Humanin 570382-85-3 [D-Ser14]-Humanin is a biologically active peptide in which the Ser14 residue of humanin is changed from L-form to D-form.
AAKLVFF V113880 AAKLVFF 1038400-67-7 AAKLVFF is an oligopeptide that can self-assemble into nanotubes.
ABri V118479 ABri 241145-90-4 ABri is an amyloid subunit composed of 34 amino acids. It exhibits heterogeneity at both its N-terminus and C-terminus and has no sequence homology with any known amyloid protein.
AC 253 V71399 AC 253 151804-79-4 AC 253 is an antagonist of amylin, inhibiting 125I-adrenomedullin binding, with IC50 of 25 nM.
Ac-BIM-acid bromide V118560 Ac-BIM-acid bromide Ac-BIM-acid bromide is an acridine derivative that can significantly inhibit the fibrotic effects of amyloid protein.
Acetly-β Amyloid(15-20), Amide V71397 Acetly-β Amyloid(15-20), Amide 189064-06-0 Acetly-β Amyloid (15-20), Amide is a polypeptide fragment.
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