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Beta Amyloid

Beta Amyloid

As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.

Beta Amyloid related products

Structure Cat No. Product Name CAS No. Product Description
Aβ aggregation-IN-3 V110818 Aβ aggregation-IN-3 Aβ aggregation inhibitor-IN-3 (compound B7) is an Aβ aggregation inhibitor.
Aβ aggregation-IN-4 V111796 Aβ aggregation-IN-4 603113-07-1 The Aβ aggregation inhibitor IN-4 can alleviate the neurotoxicity of β-amyloid (Aβ) and significantly reduce the level of Aβ oligomer complexes (Aβ-OCs).
Aβ aggregation-IN-5 V109160 Aβ aggregation-IN-5 The Aβ aggregation inhibitor IN-5 is an amyloid-β protein aggregation inhibitor that can cross the blood-brain barrier.
Aβ Fibrillization modulator 1 V71395 Aβ Fibrillization modulator 1 2847131-53-5 Aβ Fibrillization modulator 1 can stabilize Aβ monomer.
Aβ-IN-10 V93241 Aβ-IN-10 Aβ-IN-10 (compound Alz-5) is a bifunctional copper chelator and an inhibitor of amyloid-β (Aβ), which can interact with Aβ aggregates and reduce their neurotoxicity.
Aβ-IN-6 V78525 Aβ-IN-6 Aβ-IN-6 reduces proinflammatory cytokine release from microglia.
Aβ-IN-7 V78330 Aβ-IN-7 Aβ-IN-7 (compound 5a) is a potent inhibitor of Aβ aggregation.
Aβ-IN-8 V78331 Aβ-IN-8 Aβ-IN-8 (compound 7e) is a potent inhibitor of Aβ aggregation.
Aβ-IN-9 V102240 Aβ-IN-9 Aβ-IN-9 (compound 6i) is an amyloid β protein (Aβ) aggregation inhibitor.
Aβ/tau aggregation-IN-1 V71369 Aβ/tau aggregation-IN-1 2252162-81-3 Aβ/tau aggregation-IN-1 is a potent inhibitor of Aβ1-42 β-sheets formation and tau aggregation.
Aβ/tau aggregation-IN-3 V71416 Aβ/tau aggregation-IN-3 1210750-32-5 Aβ/tau aggregation-IN-3 is a potent amyloid aggregation inhibitor (antagonist) with IC50 of 0.85 μM as measured by Aβ-thioflavin T (Aβ-ThT) functional aggregation.
Aβ1-14-εK-KKK-MvF5 Th acetate V87775 Aβ1-14-εK-KKK-MvF5 Th acetate Aβ1-14-εK-KKK-MvF5 Th acetate is the acetate form of Aβ1-14-εK-KKK-MvF5 Th.
Aβ1–42 aggregation inhibitor 2 V85063 Aβ1–42 aggregation inhibitor 2
Aβ42 agonist-1 V71390 Aβ42 agonist-1 50635-12-6 Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation.
Aβ42 agonist-2 V71376 Aβ42 agonist-2 6314-40-5 Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation.
Aβ42-IN-4 V85095 Aβ42-IN-4 2387822-02-6
Aβ42-IN-5 V84203 Aβ42-IN-5
Beta-Amyloid (15-21) (Beta-Amyloid (15-21)) V71445 Beta-Amyloid (15-21) (Beta-Amyloid (15-21)) 365537-52-6 β-amyloid (15-21) is a fragment of the β-amyloid peptide with potential role in the neurological field.
BIBD-124 V71413 BIBD-124 2716871-93-9 BIBD-124 binds amyloid (Aβ) plaques with IC50 of 9.51 nM.
Biotin-Ahx-β-Amyloid (1-40) V71405 Biotin-Ahx-β-Amyloid (1-40) 1802086-72-1 Biotin-Ahx-β-Amyloid (1-40) is a biologically active peptide.
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