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Sigma Receptor

Sigma Receptor

Sigma receptors (subtypes sigma-1 and sigma-2) are a unique class of binding sites expressed throughout the mammalian body.Although the natural ligand for these sites is unknown, steroid hormones—especially progesterone—amines derived from sphingolipids, and N,N-dimethyltryptamine—all have a relatively high affinity for binding.

The sigma-1 receptor (σ1R) is a chaperone protein that resides in the endoplasmic reticulum (ER) and functions as an inter-organelle signaling modulator. Numerous biological processes are impacted by it, such as nociception, drug addiction, cardiac activity, cancer, stroke, memory, and Alzheimer's disease. Numerous human tumors exhibit overexpression of the sigma-2 (σ2R) receptor. Its status as a proliferating tumor biomarker has been confirmed.

Sigma Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(±)-PPCC V93275 (±)-PPCC 932736-90-8 (±)-PPCC is a sigma-1 agonist that primarily interacts with the sigma-1 receptor with a Ki of 1.5 nM.
(±)-PPCC hemioxalate V87843 (±)-PPCC hemioxalate 932736-91-9 (±)-PPCC hemioxalate is a compound with sigma-1 receptor modulatory activity.
(±)-PPCC oxalate V84311 (±)-PPCC oxalate 1781628-91-8
4-IBP V3950 4-IBP 155798-08-6 4-IBP is a novel and selective σ1 (sigma1) agonist with high affinity for the σ1 receptor with Ki of 1.7 nM and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
AB21 hydrochloride V87845 AB21 hydrochloride 3026677-24-4 AB21 hydrochloride is a potent and selective S1R antagonist with Ki values of 13 nM and 102 nM for S1R and S2R, respectively.
AB21oxalate V78890 AB21oxalate AB21 oxalate is a potent and specific S1R antagonist (inhibitor) with Ki of 13 nM and 102 nM for S1R and S2R, respectively.
AD353 V103727 AD353 AD353 is a selective sigma-1 receptor ligand.
Anavex2-73 HCl V7110 Anavex2-73 HCl 195615-84-0 Anavex2-73 (Anavex-273; AE-37) HCl is a novel and potent muscarinic/σ1 ( Sigma-1) ligand/agonist (IC50 = 860 nM) with therapeutic potential for treating Alzheimer's disease.
Antidepressant agent 3 V80042 Antidepressant agent 3 Antidepressant agent 3 is an orally bioactive antidepressant.
BD 1047 dihydrobromide V2985 BD 1047 dihydrobromide 138356-21-5 BD1047 dihydrobromide (BD-1047) is a selective functional antagonist of sigma receptors (σ receptors) with antipsychotic activity and may be used for schizophrenia.
BD-1047 V129953 BD-1047 138356-20-4 BD-1047 is a selective sigma receptor antagonist.
BD1063 HCl V4741 BD1063 HCl 206996-13-6 BD-1063 HCl (BD1063 hydrochloride) is a novel, potent and selective sigma receptor antagonist with the potential for treatingalcoholism.
Broussoflavonol F V71977 Broussoflavonol F 162558-94-3 Broussoflavonol F has xanthine oxidase inhibitory activity.
BS148 V116166 BS148 2162116-09-6 BS148 is a selective σ-2 receptor (S2R) agonist with a Ki value of 20 nM.
CM304 free base V108977 CM304 free base 1350296-21-7 CM304 free base (FTC-146) is a potent S1R antagonist.
DuP 734 V70037 DuP 734 135135-87-4 DuP 734 is a sigma receptor antagonist.
EST-64454盐酸盐 V2275 EST64454 HCl 1950569-11-5 EST64454 HCl is a selective and orally bioactive sigma-1 receptor blocker (antagonist) with Ki of 22 nM.
EST64454 V94242 EST64454 1351438-26-0 EST64454 (Compound 9k) is a selective, orally active sigma-1 receptor antagonist with Ki of 22 nM.
Eupatoriochromene V71980 Eupatoriochromene 19013-03-7 Eupatoriochromene is a benzopyran compound with inhibitory activity against xanthine oxidase (XO).
Fraxamoside V71974 Fraxamoside 326594-34-7 Fraxamoside is a competitive xanthine oxidase inhibitor (antagonist) with IC50 of 16.1 μM and Ki of 0.9 μM.
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