SGLTs (Sodium-dependent glucose cotransporters) are a family of glucose transporters and contribute to glucose reabsorption.SGLT1 and SGLT2, which belong to the SLC5A gene family, are the two most well-known members of the SGLT family. The two transporters play two major roles in maintaining glucose homeostasis: first, via SGLT1, they absorb glucose from the diet in the small intestine, and second, through SGLT2 and, to a lesser extent, SGLT1, they re-absorb the filtered glucose in the kidney's tubular system, which puts glucose back into the bloodstream and stops urine glucose loss. For diabetes and cardiomyopathy, SGLT1 and SGLT2 have been suggested as a novel therapeutic approach.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V5117 | Phlorizin (Floridzin; NSC 2833) | 60-81-1 | Phlorizin (phloridzin), a glucoside of phloretin which is a dihydrochalcone and a family of bicyclic flavonoids, is a potent and non-selective competitive SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. |
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V1501 | Sotagliflozin (LX4211) | 1018899-04-1 | Sotagliflozin (formerly known as LP-80203; LX4211; LP80203; LX-4211; Zynquista), an antidiabetic drug approved for treating type 1 diabetes in EU, is a potent, orally bioavailable, and dual SGLT1/SGLT2 inhibitor with antidiabetic activity. |
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V12578 | Bexagliflozin | 1118567-05-7 | Bexagliflozin (formerly known as THR 1442; EGT1442; EGT-1442; Brenzavvy) is a potent and selective SGLT2 inhibitor with antidaibetic activity. |
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V1498 | Dapagliflozin (BMS-512148) | 461432-26-8 | Dapagliflozin (formerly known as BMS-512148; trade names Farxiga in the US and Forxiga in the EU) is a potent and selective hSGLT2 (sodium-glucose transport proteins) inhibitor with anti-diabetic activity. |
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V28640 | Dapagliflozin ((2S)-1,2-propanediol hydrate) | 960404-48-2 | Dapagliflozin ((2S)-1,2-propanediol hydrate) is the S-isomer of Dapagliflozin 1,2-propanediol hydrate, which is an antidiabetic drug used to treat diabetes mellitus (DM). |
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