The different subtypes of the melanocortin (MC) receptors, which are a subfamily of G-protein-coupled receptors (GPCRs), play a variety of physiological roles, including pigmentation, steroid secretion, energy homeostasis, and food intake. Five G-protein-coupled receptors (MC1R-MC5R) make up the melanocortin receptor (MCR) family. The MC1R regulates pigmentation, the MC2R is an essential part of the hypothalamic-pituitary-adrenal axis, the MC3R, MC4R, and MC5R are involved in exocrine function, and they all play a significant role in energy homeostasis.
A number of neuropeptides known as melanocortins, such as adrenocorticotropic hormone (ACTH) and,, and -melanocyte-stimulating hormones (MSHs), activate MCRs. Pro-opiomelanocortin, a common polypeptide precursor that is primarily expressed in the hypothalamus and pituitary, is processed post-translationally to produce melanocortins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76692 | Nonapeptide-1 acetate salt (Melanostatine-5 acetate salt) | Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). | |
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V85012 | Palmitoyl tetrapeptide-20 TFA (PTP20 TFA) | ||
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V51034 | PF-07258669 | 2755890-53-8 | PF-07258669 is a melanocortin 4 receptor (MC4) antagonist. |
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V70565 | PG-931 | 667430-81-1 | PG-931 is an analogue of SHU 9119. |
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V81105 | PG-931 TFA | PG-931 TFA is an analogue of SHU 9119. | |
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V70584 | PG106 | 944111-22-2 | PG106 is a potent and specific hMC3 receptor antagonist (IC50= 210 nM) and inactive against hMC4 receptor (EC50=9900 nM) and hMC5 receptor. |
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V76636 | PG106 TFA | PG106 TFA is a potent and specific hMC3 receptor antagonist (IC50= 210 nM) and inactive against hMC4 receptor (EC50=9900 nM) and hMC5 receptor. | |
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V70563 | Resomelagon acetate (AP1189 acetate) | 1809420-72-1 | Resomelagon (AP1189) acetate is an orally bioavailable agonist of melanocortin receptors (MR)such as MC1 and MC3. |
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V86668 | Resomelagon methanesulfonate | 2933183-20-9 | Resomelagon methanesulfonate (AP1189 methanesulfonate) is the mesylate salt form of Resomelagon. |
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V70572 | TCMCB07 | 1456699-27-6 | TCMCB07 is a cyclic nonapeptide that is an orally bioactive and brain-penetrating melanocortin receptor 4 (MC4R) antagonist. |
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V76445 | TCMCB07 TFA | TCMCB07 TFA is a cyclic nonapeptide and an orally bioactive and brain-penetrating melanocortin receptor 4 (MC4R) antagonist. | |
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V70570 | Tetrapeptide-1 | 1632354-04-1 | Tetrapeptide-1 is a biologically active peptide with antioxidant effects that has been reported as an ingredient of cosmetics. |
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V70562 | α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) | 171869-93-5 | α-MSH (alpha-melanocyte-stimulating hormone) TFA, as an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist/activator with anti-inflammatory and antipyretic effects. |
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V86665 | β-Melanocyte Stimulating Hormone (MSH), human TFA | β-Melanocyte Stimulating Hormone (MSH), human TFA, is a 22-mer peptide that is an endogenous melanocortin-4 receptor (MC4-R) agonist. | |
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V81815 | γ1-MSH TFA | γ1-MSH TFA is a melanocortin MC3 receptor agonist/activator with a Ki of 34 nM for rat MC3 receptors. | |
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V28769 | Setmelanotide | 920014-72-8 | Setmelanotide (BIM-22493; RM-493; IRC-022493; Imcivree) is a novel, selective and peptidyl agonist of melanocortin 4 receptor (MC4R) that has been approved in 2020 for use as an anti-obesity medication for the treatment of genetic obesity. |
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V12340 | Bremelanotide | 189691-06-3 | Bremelanotide (PT-141; PT141; PT 141; Vyleesi), a peptide analogue of alpha-MSHpeptide acting as a melanocortin receptor agonist approved in 2019 for the treatment of hypoactive sexual desire disorder in premenopausal women. |
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V29413 | Melanotan I (Afamelanotide; CUV1647) | 75921-69-6 | Afamelanotide (Melanotan I; MT-I; CUV-1647; MBJ05; trade name Scenesse) is a synthetic peptide analog of α-melanocyte stimulating hormone (α-MSH), acting as a melanocortin receptor agonist and has been approved for use to prevent skin damage from the sun in people with erythropoietic protoporphyria in EU and USA. |
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V32521 | Bremelanotide Acetate | 1607799-13-2 | Bremelanotide Acetate (PT-141; PT141; PT 141; Vyleesi), the acetatea salt of Bremelanotide, is a peptide analogue of alpha-MSH peptide acting as a melanocortin receptor agonist. |
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