The acetylcholine receptors known as mAChRs (muscarinic acetylcholine receptors) are found in the cell membranes of some neurons and other cells. The primary end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system is one of their many functions. Because they are more sensitive to muscarine than to nicotine, mAChRs are so named. Nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also significant in the autonomic nervous system, are their counterparts. Numerous medications and other substances, such as scopolamine and pilocarpine, act as selective agonists or antagonists on these two different receptors. The brain and the autonomic ganglia are both rich sources of the neurotransmitter acetylcholine (ACh).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70548 | Tazomeline | 131987-54-7 | Tazomeline is a selective M1 muscarinic receptor agonist. |
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V2825 | TBPB | 634616-95-8 | TBPB[1-(1-2-methylbenzyl)-1,4-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one] is a novel and highly selectiveallosteric agonist Muscarinic M1 receptor (mAChR) withEC50 of 289 nM. |
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V70514 | Telenzepine dihydrochloride | 147416-96-4 | Telenzepine di-HCl is a selective and orally bioactive muscarinic M1 receptor antagonist (inhibitor) with a Ki of 0.94 nM. |
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V15146 | Tiotropium bromide | 136310-93-5 | Tiotropium Bromide (BA679BR; BA-679BR; PUR-0200; PUR0200; Spiriva) is an approved anticholinergic and bronchodilator medication used as a long-acting bronchodilator for the treatment of chronic obstructive pulmonary disease (COPD). |
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V70513 | Tiotropium bromide monohydrate (Tiotropium bromide monohydrate; BA-679 BR monohydrate) | 411207-31-3 | Tiotropium bromide (BA-679 BR) monohydrate is a long-acting muscarinic receptor blocker (antagonist). |
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V70529 | Tiotropium-d3 bromide (BA679 BR-d3) | 1127226-56-5 | Tiotropium-d3 (bromide) is the deuterated form of Tiotropium (Bromide). |
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V16571 | Tolterodine | 124937-51-5 | Tolterodine (also known as PNU-200583E) is a tartrate salt of tolterodine that is a potent and competitive muscarinic receptor antagonist. |
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V70551 | Tolterodine-d14 hydrochloride ((R)-(+)-Tolterodine-d14 hydrochloride; (+)-Tolterodine-d14 hydrochloride; (R)-Tolterodine-d14 hydrochloride; PNU-200583-d14 hydrochloride) | 1217645-16-3 | Tolterodine-d14 (HCl) is the deuterium labelled form of Tolterodine HCl. |
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V81619 | Trihexyphenidyl-d5 hydrochloride | Trihexyphenidyl-d5 ( HCl) is the deuterated form of Trihexyphenidyl ( HCl). | |
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V70552 | Tropicamide-d3 (Ro 1-7683-d3) | 2673270-13-6 | Tropicamide-d3 is the deuterated form of Tropicamide. |
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V78932 | Trospium-d8 chloride (trospium d8 chloride) | Trospium-d8 (chloride) is the deuterated form of Trospium chloride. | |
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V3643 | Umeclidinium bromide | 869113-09-7 | Umeclidinium bromide (formerly GSK-573719; GSK573719A; Incruse Ellipta) is a novel and inhaled long-acting muscarinic antagonist (LAMA) with the potential for treatment of pulmonary diseases (e.g. COPD). |
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V76389 | Umeclidinium-d10 bromide (GSK573719A-d10) | Umeclidinium-d10 (bromide) is the deuterated form of Umeclidinium bromide. | |
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V78404 | Umeclidinium-d5 bromide (GSK573719A-d5) | Umeclidinium-d5 (bromide) is the deuterated form of Umeclidinium bromide. | |
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V81742 | VLVNTFCDSCIPKTYWNLGY TFA | VLVNTFCDSCIPKTYWNLGY TFA is an antigenic peptide of the M3 muscarinic receptor (M3R). | |
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V20318 | VU0119498 | 79183-37-2 | VU0119498 is a positive allosteric modulator (PAM) of pan-Gq mAChR M1, M3, and M5 with EC50s of 6.04, 6.38, and 4.08 µM, respectively. |
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V2229 | VU0238441 | 85511-68-8 | VU0238441 is a pan-muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50 of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM and > 10 for M1, M2, M3, M5 and M4, respectively. |
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V3036 | VU0357017 HCI | 1135242-13-5 | VU0357017 HCI (formerly CID-25010775) is a potent and highly selective M1 agonists that appear to act at an allosteric site to activate the receptor with EC50 of 477 ± 172 nM and pEC50 of 6.37 ± 0.15). |
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V28096 | VU0453595 | 1432436-13-9 | VU0453595 is a selective, systemically active M1 positive allosteric modulator (PAM) (PAM, EC50=2140 nM) that may be utilized in the research/study of schizophrenia. |
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V70505 | VU10010 | 633283-39-3 | VU10010 is a specific allosteric enhancer of M4 mAChR with EC50 of 400 nM. |
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