Members of the G protein-coupled receptor family of integral membrane proteins, the LPL Receptor (Lysophospholipid Receptor) group are crucial for lipid signaling. There are eight LPL receptors in humans, and different genes each encode one of them. Other names for these LPL receptor genes include "Edg." In the cell membrane, LPL receptor ligands bind to and activate their corresponding receptors. The activated receptor can have a variety of effects on the cell, depending on the ligand, receptor, and type of cell involved. These include primary effects such as adenylyl cyclase inhibition and calcium release from the endoplasmic reticulum, as well as secondary effects such as cell proliferation and apoptosis prevention. Type: S1PR1, S1PR2, S1PR3, S1PR4, S1PR5, LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, and LPAR6.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V40955 | Lysophosphatidic acid | 325465-93-8 | Lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2, a glycerophospholipid signaling ligand molecule and ligand activator for EDG-2, EDG-4, and EDG-7. |
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V81848 | Mevalonic acid 5-pyrophosphate tetralithium (5-Diphosphomevalonic acid tetralithium; Mevalonic acid 5-diphosphate tetralithium) | 108869-00-7 | Mevalonic acid 5-pyrophosphate (5-Diphosphomevalonic acid) tetralithium is an endogenously produced metabolite of the mevalonate pathway. |
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V23317 | Mocravimod (KRP-203) HCl | 509088-69-1 | Mocravimod HCl (KRP203) is a novel and potent sphingosine 1-phosphate receptor type 1 agonist, acting as an immunosuppressant that ameliorates atherosclerosis in LDL-R-/- mice. |
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V75441 | ONO-0740556 | 2250210-69-4 | ONO-0740556 is a potent Gi-coupled human lysophosphatidic acid receptor 1 (LPA1) agonist with EC50 of 0.26 nM. |
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V2583 | ONO-7300243 | 638132-34-0 | ONO-7300243 (ONO 7300243, ONO7300243)is a novel, potent and selective antagonist of LPA1(Lysophosphatidic Acid Receptor) with an IC50 of 160 nM. |
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V75456 | ONO-9780307 | 856691-44-6 | ONO-9780307 is a specific LPA1 (lysophosphatidic acid receptor 1) antagonist (inhibitor) with IC50 of 2.7 nM. |
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V75458 | Ozanimod hydrochloride (RPC-1063 hydrochloride) | 1618636-37-5 | Ozanimod (RPC-1063) HCl is a sphingosine 1-phosphate (S1P) receptor modulator that selectively binds to S1P receptor subtype 1 (S1P1) and S1P5 (S1P5) with high affinity. |
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V2460 | Pluronic F-68 | 9003-11-6 | Pluronic F-68 (P188, Poloxamer 188, MST-188), a non-ionic surfactant and polyol, is a PEO-PPO-PEO polymer (the form polyethylene oxide-polypropylene oxide-polyethylene oxide). |
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V75447 | RBM10-8 | 2407372-42-1 | RBM10-8 is an irreversible recombinant human sphingosine-1-phosphate lyase (hS1PL) inhibitor. |
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V75462 | S1p receptor agonist 2 | 1354908-17-0 | S1p receptor agonist 2 (compound 1) is an agonist of the S1P5 receptor and is more selective than the S1P1 and/or S1P3 receptors. |
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V75451 | S1P1 agonist 4 | 1883345-11-6 | S1P1 agonist 4 performed better both in terms of potency (EC50 < 0.05 mg/kg) and predicted half-life in humans (t1/2 ∼ 5 days). |
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V75450 | S1P1 agonist 5 | 2760666-20-2 | S1P1 agonist 5 is a selective and orally bioactive S1P1 agonist. |
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V75452 | S1P1 agonist 6 | 2433782-42-2 | S1P1 agonist 6 (Compound I) is an S1P1 agonist. |
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V75448 | S1P1 agonist 6 hemicalcium | 2941310-03-6 | S1P1 agonist 6 hemicalcium (Compound I) is an S1P1 agonist. |
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V75453 | S1P2 antagonist 1 | 2262402-83-3 | S1P2 antagonist 1 is an orally bioavailable anti-fibrotic S1P2 antagonist. |
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V75463 | S1P5 receptor agonist-1 | 2373330-78-8 | S1P5 receptor agonist (activator)-1 (example 6) is a potent and specific S1P5 receptor agonist (activator) with EC50 of 20 nM. |
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V75455 | S1PR1 modulator 1 | 2328109-05-1 | S1PR1 modulator 1 is a selective S1PR1 inhibitor (antagonist) with pIC50 of 7.6, and its selectivity is more than 40 and 80 times higher than that of S1PR subtype S1PR2/3/4. |
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V75446 | S1PR1 Radioligand 1 | 2845249-11-6 | S1PR1 Radioligand 1 (compound 6 h) is a specific radioligand for S1PR1, IC50 = 8.7 nM. |
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V75459 | SAR247799 (S1P1 agonist 3) | 1315311-14-8 | SAR247799 (S1P1 agonist 3) is an orally bioactive, selective G protein-biased sphingosine-1 phosphate receptor-1 (S1P1) agonist/activator with EC50 of 12.6-493 in S1P1-overexpressing cells and HUVECs. |
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V14699 | SEW2871 | 256414-75-2 | SEW2871 (SEW-2871) is a S1P1 agonist (sphingosine-1-phosphate type 1 receptor agonist) with EC50 of 13.8 nM. |
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