Glucocorticoid Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind.The GR regulates the genes that control development, metabolism, and immune response and is expressed in almost all body cells. The regulation of gene transcription is the main mechanism by which the glucocorticoid receptor functions when it binds to glucocorticoids.The cell's cytosol is home to the unbound receptor. The receptor-glucocorticoid complex can proceed in one of two ways after the glucocorticoid and receptor are bound together. By preventing other transcription factors from moving from the cytosol into the nucleus, the activated GR complex controls the expression of anti-inflammatory proteins in the nucleus or suppresses the expression of pro-inflammatory proteins in the cytosol. Dexamethasone is an agonist, while cyproterone acetate and RU486 are GR antagonists. Progesterone and DHEA also negatively affect the GR.

Glucocorticoid Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V102871	(22R)-Budesonide	51372-29-3	(22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of budesonide.
V88954	(R)-GSK866	1094607-80-3	(R)-GSK866 is the R-enantiomer of GSK866.
V86855	2-O-trans-p-Coumaroylalphitolic acid	67911-63-1	2-O-trans-p-Coumaroylalphitolic acid (Zj7) is a triterpenoid extracted from the jujube plant.
V103092	20α-Dihydro prednisolone	15847-24-2	20α-Dihydroprednisolone is a metabolite of prednisolone.
V86852	21-Desacetyldeflazacort-d5		21-Desacetyldeflazacort-d5 is the deuterated form of 21-Desacetyldeflazacort.
V107579	6b-Hydroxy triamcinolone acetonide	3869-32-7	6b-Hydroxytriamcinolone is a metabolite of the corticosteroid triamcinolone, which is formed from triamcinolone by cytochrome P450 (CYP) isoenzymes CYP3A4, CYP3A5, and CYP3A7.
V103145	6β-Hydroxy dexamethasone	55879-47-5	6β-Hydroxydexamethasone is the active metabolite of the synthetic glucocorticoid dexamethasone.
V104000	ABBV-154		ABBV-154 is an anti-TNF antibody-drug conjugate (ADC).
V104001	ABBV-3373		ABBV-3373 is an anti-TNF antibody-drug conjugate (ADC).
V106072	Cortolone	516-42-7	Alpha-Cortolone is a metabolite of the glucocorticoid cortisol (hydrocortisone).
V103173	Fluticasone 17β-carboxylic acid	28416-82-2	Fluticasone 17β-carboxylic acid is a synthetic intermediate of the glucocorticoid fluticasone propionate.
V86859	GA32	1386811-71-7	GA32 (compound 58r) is a potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively.
V106781	Glucocorticoid receptor activator 1	14593-25-0	Glucocorticoid receptor activator 1 (Compound A) is a phenyl nitrogen heterocyclic precursor and an activator of the glucocorticoid receptor (GR).
V105159	Glucocorticoid receptor drug-linke 1	3048601-02-8	Glucocorticoid receptor drug linker 1 is a drug linker conjugate that can be used to synthesize ADCs targeting BDCA2.
V51050	Glucocorticoid receptor modulator 1	2868357-11-1	Glucocorticoid receptor modulator 1 is a potent epidermal agent for NF-κB and AP-1, with IC50s of 9 nM and 130 nM, respectively.
V86856	Glucocorticoid receptor modulator 3	2688785-13-7	Glucocorticoid receptor modulator 3 (Payload 6) is a thioester-containing glucocorticoid receptor modulator (IC50=0.6 nM).
V86125	GSK866	1991970-93-4
V86854	Hydrocortisone hemisuccinate hydrate	83784-20-7	Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID).
V97417	IONIS-GCCRRx	1431900-72-9	IONIS-GCCRRx (ISIS 426115) is a glucocorticoid receptor antagonist, a 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO).
V97431	IONIS-GCCRRx sodium		IONIS-GCCRRx (ISIS 426115) sodium is a glucocorticoid receptor antagonist and 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO).