By making blood vessels tighten, the angiotensin-converting enzyme (ACE) indirectly raises blood pressure. Angiotensin I is changed by ACE into angiotensin II, which tightens the blood vessels. The renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body, is made up of ACE, angiotensin I, and angiotensin II. Cells in the endothelium (inner layer) of blood vessels secrete ACE in the lungs and kidneys.It serves two main purposes: In a substrate concentration-dependent manner, ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Bradykinin, a potent vasodilator, and other vasoactive peptides are broken down by ACE. In order to treat conditions like high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus, ACE inhibition is a goal. By inhibiting ACE (using ACE inhibitors), angiotensin II production and bradykinin metabolism are reduced, which causes a systematic dilation of the arteries and veins and a reduction in arterial blood pressure.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V72996 | (R)-MLN-4760 | 305335-29-9 | (R)-MLN-4760, the less active R-isomer of MLN-4760, is an ACE2 inhibitor (antagonist) with IC50 of 8.4 μM. |
|
V87314 | (±)8(9)-EpETE | 851378-93-3 | (±)8(9)-EpETE ((±)8,9-EEQ; (±)8,9-epoxy Eicosatetraenoic acid) can be converted to epoxyeicosatetraenoic acid (EpETE) by multiple cytochrome P450 isozymes. |
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V16693 | 4-Hydroxytamoxifen | 68047-06-3 | 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally bioavailable, selective estrogen receptor modulator (SERM). |
![[Tyr6]-Angiotensin II](http://www.invivochem.com/upload/1124/V73020.png)
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V73020 | [Tyr6]-Angiotensin II | 52634-95-4 | [Tyr6]-Angiotensin II is a bioactive peptide fragment that binds to angiotensin converting enzyme 2. |
|
V85768 | Abz-LFK(Dnp)-OH | 1217437-30-3 | |
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V85747 | Abz-SDK(Dnp)P-OH | 860313-53-7 | |
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V73001 | Abz-Ser-Pro-3-nitro-Tyr | 553644-01-2 | Abz-Ser-Pro-3-nitro-Tyr is a substrate of ACE2 (ACE (angiotensin-converting enzyme)-2). |
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V120050 | AC-SDKP-NH2 | 194484-75-8 | AC-SDKP-NH2 is a substrate peptide of angiotensin-converting enzyme (ACE). |
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V50469 | AD-012 | 3010931-94-6 | AD012 is a cACE/NEP dual inhibitor. |
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V50460 | AD-013 | 3010931-81-1 | AD013 is a cACE/NEP dual inhibitor. |
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V72991 | Alamandine | 1176306-10-7 | Alamandine is a vasoactive peptide, a member of the renin-angiotensin system (RAS), and an endogenous ligand of the G protein-coupled receptor MrgD. |
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V109922 | Angiotensin Converting Enzyme, Rabbit | Rabbit angiotensin-converting enzyme (EC 3.4.15.1) indirectly raises blood pressure by causing vasoconstriction. | |
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V110223 | Angiotensin Converting Enzyme, Rat | Rat angiotensin-converting enzyme (EC 3.4.15.1) indirectly raises blood pressure by causing vasoconstriction. | |
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V87311 | BKIDC-1553 | 1951431-34-7 | BKIDC-1553 is an orally available antiglycolytic agent and kinase inhibitor derivative with a predicted half-life of approximately 17 h in humans. |
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V72998 | Bradykinin potentiator B (Bradykinin potentiating peptide B) | 30892-86-5 | Bradykinin potentiator B is the venom of Agkistrodon halys blomhoffi. |
|
V73012 | Camellianin B (Camellia flavonoid glycoside B) | 109232-76-0 | Camellianin B, a flavonoid, is a metabolite of Camellianin A. |
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V87319 | Canvircept | Canvircept is a monoclonal antibody against ACE2. | |
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V87321 | Casein hydrolysate | 65072-00-6 | Casein hydrolysate is the hydrolysis product of casein. |
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V111012 | CEI12 | 26046-92-4 | CEI12 is an angiotensin I converting enzyme inhibitor (ACEI) polypeptide that can be isolated from αs1-casein peptide. |
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V95275 | Cilazapril hydrochloride | 88824-78-6 | Cilazapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and congestive heart failure. |
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