Integrins, a family of heterodimeric adhesion receptors for various extracellular matrices, have repeatedly been linked to being important initiators and promoters of ovarian cancer growth and progression. Aggressive ovarian tumors exhibit significantly elevated levels of several RGD-based integrin family members, including integrins 5-1 and v3 or v5. These adhesion receptors appear to encourage cell adhesion, survival, motility, and invasion during the development of an ovarian tumor or the spread of its metastatic disease. Notably, the activation of FAK and its downstream signaling, including the PI3K/Akt- and Ras/MAPK-dependent pathways, is crucial for the functions of these integrins.
Transmembrane proteins called integrins serve as important receptors for cell-extracellular matrix (ECM) and cell-cell adhesion.These molecules can be modified, and the v integrin family in particular, has shown to have significant effects on fibrosis in a variety of organs and disease states. According to numerous studies, the latent transforming growth factor (TGF)- is activated by the integrins v3, v5, v6, and v8 in pre-clinical fibrosis models, modulating the fibrotic process.
One of the 18 different types of subunits that are known to exist and one of the eight different types of subunits that are known to exist are typically non-covalently paired to form each integrin. There are currently 24 different heterodimers in total. The fact that the v subunit can form heterodimers with the 1, 3, 5, 6 or 8 subunits and that the 1 subunit can associate with a wide variety of subunits from 1 to 11 shows that not all theoretically possible and subunit pairs form. It's intriguing to note that a variety of v integrins appear to share a common function in TGF- activation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75805 | Zalunfiban acetate (RUC-4 acetate) | 2376629-15-9 | Zalunfiban (RUC-4) acetate is a potent and specific platelet αIIbβ3 antagonist (IC50=45 nM). |
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V73470 | Zalunfiban dihydrochloride (RUC-4 dihydrochloride) | Zalunfiban (RUC-4) di-HCl is a potent and specific platelet αIIbβ3 antagonist (IC50=45 nM). | |
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V75800 | α5β1 integrin agonist-1 | 2756557-83-0 | α5β1 integrin agonist-1, as an α5β1 integrin agonist, can selectively deliver 5-FU into tumor cells and successfully cause tumor cell death. |
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V75803 | α7β1 integrin modulator-1 | 849121-82-0 | α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. |
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V75801 | αvβ1 integrin-IN-2 | 2234874-68-9 | αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM and 33 nM, respectively. |
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V75806 | αvβ5 integrin-IN-1 | 2615912-33-7 | αvβ5 integrin-IN-1 is the first potent and specific αvβ5 integrin inhibitor (pIC50 = 8.2). |
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V75807 | αvβ6 integrin inhibitor 2 | 313709-47-6 | αvβ6 integrin inhibitor 2 is a potent αvβ6 integrin inhibitor (antagonist) with IC50 of 96.5 nM (WO2020081154A1, Example 19). |
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V81798 | αvβ6-BP | αvβ6-BP is a selective αvβ6-binding peptide that may be utilized in molecular imaging studies. | |
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V66860 | αvβ6-BP TFA | αvβ6-BP TFA is a selective αvβ6-binding peptide that may be utilized in molecular imaging studies. |
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