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    MNS (NSC 170724, MDBN)
    MNS (NSC 170724, MDBN)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1320
    CAS #: 1485-00-3Purity ≥98%

    Description: MNS (NSC170724; NSC-170724; NSC 170724; 5-(2-Nitrovinyl)benzodioxole)) is a novel, potent and selective TKI-tyrosine kinase inhibitor with anti-platelet activity. It inhibits multiple kinases such as Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. 

    References: Mol Pharmacol. 2006 Oct;70(4):1380-9; J Biol Chem. 2011 May 13;286(19):16546-54. 

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    Molecular Weight (MW)193.16
    FormulaC9H7NO4 
    CAS No.1485-00-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 39 mg/mL (201.9 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Solubility (In vivo)2% DMSO+corn oil: 5mg/mL  
    SMILES Code and Synonyms
    O=[N+]([O-])/C=C/C1=CC(OCO2)=C2C=C1; NSC 170724; 5-(2-Nitrovinyl)benzodioxole; SYK Inhibitor III; NSC 170724; NSC-170724; NSC170724; 5-(2-Nitrovinyl)benzodioxole


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    In Vitro

    In vitro activity: MNS (3,4-methyl-enedioxy-β-nitrostyrene) completely inhibits 2 μM U46619-(a thromboxane A2 mimic), 5 μM ADP-, 100 μM arachidonic acid-(AA), 10 μg/ml collagen-, and 0.1 U/ml thrombin-induced platelet aggregation in a concentration-dependent manner with IC50 of 2.1 μM, 4.1 μM, 5.8 μM, 7.0 μM, and 12.7 μM, respectively. MNS inhibits platelet aggregation caused by either the calcium ionophore A23187 (1 μM) or the protein kinase C (PKC) activator PDBu (200 nM) with IC50 of 25.9 μM and 4.8 μM, respectively. MNS (20 μM) decreases dthrombin-induced P-selectin expression on platelets to levels comparable to those observed in PGE1-treated platelets. MNS (20 μM) markedly inhibits thrombin-but not PDBu-induced MARCKS phosphorylation in platelets. MNS (20 μM) markedly inhibits protein tyrosine phosphorylation at either 0.5 min or 3 min after thrombin or collagen stimulation in platelets. MNS stimulates UbG76V-GFP and ODD-Luc degradation with IC50 of 1.6 μM and 5.9 μM, respectively. MNS inhibits MG132-induced accumulation of the reporter with IC50 of 2.1 μM. MNS inhibits Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria with minimum inhibitory concentrations (MICs) of 128 mg/L. MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. MNS (3,4-Methylenedioxy-β-nitrostyrene) is equally potent as inhibitors of platelet aggregation as 3,4-dimethoxy-β-nitrostyrene. MNS (20 μM) concentration-dependently prevents ATP release from platelets stimulated by thrombin or collagen. MNS (20 μM) inhibits thrombin-induced PAC-1 binding to human platelets. 

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    ReferencesMol Pharmacol. 2006 Oct;70(4):1380-9; J Biol Chem. 2011 May 13;286(19):16546-54. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)

    Identification of 3,4-methylenedioxy-β-nitrostyrene (compound 7) as an inhibitor of UbG76V-GFP and TCRα-GFP degradation. J Biol Chem. 2011 May 13;286(19):16546-54.
     

    MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)

    Compound 7 inhibits MG132-dependent UbG76V-GFP accumulation. J Biol Chem. 2011 May 13;286(19):16546-54.


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