DNA(RNA) Synthesis

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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DNA(RNA) Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.

In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.

M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.

DNA(RNA) Synthesis related products

Cat No.	Product Name	CAS No.	Product Description
V12088	Fexinidazole	59729-37-2	Fexinidazole (Hoe239; Hoe-239) is a novel, potent and nitroimidazole-based antiparasitic agent that has been approved in 2021 by FDA as the first all-oral medication to treat African trypanosomiasis caused by Trypanosoma brucei gambiense.
V1465	Fidaxomicin (OPT-80)	873857-62-6	Fidaxomicin (formerlyOPT-80, PAR-101; PAR101; OPT80; Dificid; Dificlir; Clostomicin B1; Difimicin; Lipiarmycin; Tiacumicin B) is a narrow spectrum macrocyclic antibiotic agent and a naturally occuringfermentation product extracted from the actinomycete Dactylosporangium aurantiacum subspecies hamdenesisthat.
V21027	Filibuvir	877130-28-4	Filibuvir (PF00868554;PF-00868554) is a novel and potent NS5B inhibitor of thenon-nucleoside inhibitor (NNI) class developed for the treatment of hepatitis C.
V1448	Floxuridine	50-91-9	Floxuridine (5-fluorodeoxyuridine; Deoxyfluorouridine, FDUR, NSC-27640; FdUrD; fluorodeoxyuridine; fluorouridine deoxyribose; FUDF; 5FUDR; FUdR; WR138720) is an antimetabolite anticancer drug approved for the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.
V1379	Fludarabine (NSC 118218)	21679-14-1	Fludarabine (also known as FaraA; Fludarabinum; NSC-118218; F-ara-A; HSDB6964; NSC118218; HSDB-6964)is a potent STAT1 activation inhibitor and a DNA synthesis inhibitor that has been approved as a chemotherapeutic drug for the treatment of leukemia and lymphoma.
V1472	Fludarabine Phosphate (NSC 118218)	75607-67-9	Fludarabine phosphate (formerly F-ara-A; Fludara; Beneflur; 2FaraAMP; NSC312887; NSC-312887),the phosphate salt of Fludarabine, is an adenosine analog and potent STAT-1 activation inhibitor with potential antineoplastic activity.
V1447	Flunarizine 2HCl	22348-32-9	Flunarizine 2HCl (formerly R-14950;KW3149; R14950;KW 3149; trade name Sibelium), the dihydrochloride salt form of Flunarizine,is a selective calcium entry/channel blocker with calmodulin binding properties and anti-histamine H1 activity.
V1462	Fluorouracil (5-Fluoracil, 5-FU)	51-21-8	Fluorouracil (formerly 5-FU; NSC-19893; NSC19893; 5-Fluorouracil), an analogue of uracil, is an approved anticancer medication acting asa potent DNA/RNA synthesis inhibitor.
V1475	Flupirtine maleate (D 9998)	75507-68-5	Flupirtine maleate(W2964; W-2964M; D9998;W-2964; D-9998; Katadolon), the maleate salt form of Flupirtine, is a centrally acting non-opioid analgesic agent and a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
V5234	Folic acid (Vitamin B9; Vitamin M)	59-30-3	Folic acid (also known as Vitamin M; Vitamin B9; folate) is a one of the B vitamins and is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis.
V34803	Foscarnet trisodium hexahydrate (Trisodium phosphonoformate hexahydrate; Phosphonoformic acid trisodium salt hexahydrate)	34156-56-4	Foscarnet trisodium hexahydrate is an inhibitor of viral DNA polymerase activity and reversibly inhibits viral replication.
V85130	G-quadruplex ligand 1	1023617-96-0
V32692	GC7 Sulfate	150417-90-6	GC7 Sulfate, the sulfate salt of GC-7 (N1-guanyl-1,7-diaminoheptane), is a novel and potent deoxyhypusine synthase (DHPS) inhibitor that inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
V1478	Gemcitabine	95058-81-4	Gemcitabine (formerly LY-188011, NSC-613327; LY188011, NSC613327; dFdC; dFdCyd; trade name: Gemzar), an approved antimetabolite anticancer drug, is a potent DNA synthesis inhibitor with potential antineoplastic activity.
V1423	Gemcitabine HCl	122111-03-9	GemcitabineHCl (formerly also known as LY-188011, NSC-613327; dFdC; dFdCyd; trade name: Gemzar), the hydrochloride salt of gemcitabine which is anantimetabolite anticancer drug,is a potent DNA synthesis inhibitor approved for cancer treatment.
V4299	GS-441524	1191237-69-0	GS-441524 is an active metabolite of Remdesivir (GS-5734; Veklury) which is an FDA approved antiviral drug for treating 2019-nCoV (COVID-19 pandemic, CoronaVirus) infections.
V55120	H3B-968	2912294-90-5	H3B-968 is a novel inhibitor of Werner syndrome protein (WRN), an ATPase, exonuclease, and helicase (IC50=~10 nM).
V52005	HBV-IN-4	2305897-84-9	HBV-IN-4, a phthalazinone derivative, is a novel and selective HBV DNA replication inhibitor with an IC50 of 14 nM.
V79496	hDHODH-IN-12		hDHODH-IN-12 is a potent DHODH inhibitor (antagonist) with IC50 of 0.421 μM.
V51993	Heliquinomycin	178182-49-5	Heliquinomycin is a DNA helicase (Ki: 6.8 μM) inhibitor and can inhibit the synthesis of DNA and RNA. Heliquinomycin possesses potent antibacterial action against strains of Gram-positive bacteria.