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Wee1

Wee1

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe).Wee1, a key regulator of cell cycle progression, has a molecular mass of 96 kDa. Wee1 alters cell size by preventing Cdk1 from triggering mitosis, which prevents cell division. Numerous other organisms, including mammals, have wee1 homologues. Wee1 inhibits Cdk1 by phosphorylating it at Tyr15 and Thr14, two different sites. Cdk1 is essential for the various cell cycle checkpoints' cyclin-dependent passage. The inhibition of Cdk1 by Wee1 is critical for at least three checkpoints, including the G2/M checkpoint, cell size checkpoint, and DNA damage checkpoint. It has been demonstrated that Wee1 regulates the overall expression of histones by phosphorylating histone H2B at the tyrosine 37 residue.

Wee1 related products

Structure Cat No. Product Name CAS No. Product Description
Adavosertib-C3-NH-Boc V118659 Adavosertib-C3-NH-Boc 2113725-19-0 Adavosertib-C3-NH-Boc is a target protein ligand-linker conjugate containing a Wee1 ligand and a PROTAC linker, which recruits E3 ligases.
APO-50815 V129278 APO-50815 APO-50815 is a WEE1 kinase inhibitor with an IC50 value of 9 nM in humans.
BAA-009 V129851 BAA-009 BAA-009 is a selective, orally active PKMYT1 inhibitor with an IC50 < 50 nM.
BAA-065 V129852 BAA-065 BAA-065 is a selective, orally active PKMYT1 inhibitor with an IC50 < 50 nM.
BMS-986463 V120387 BMS-986463 3025467-07-3 BMS-986463 is a CRBN E3 ligase regulator (CELMoD) and a WEE1 kinase molecule gel degrader.
CJM061 V131834 CJM061 1847445-87-7 CJM061 is a WEE1 kinase inhibitor with an IC50 value of 2.8 nM.
DB07006 V109033 DB07006 622855-60-1 DB07006 (compound 18) is a potent ATP-competitive dual inhibitor that inhibits Wee1 (IC50 = 0.030 μM) and Chk1 checkpoint kinase (IC50 = 0.018 μM).
i-AZD1775 TFA V137751 i-AZD1775 TFA 2858813-30-4 i-AZD1775 TFA is an immobilizable analogue of AZD1775.
LEB-03-144 V75886 LEB-03-144 2858812-89-0 LEB-03-144 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a C3 alkyl linker.
LEB-03-145 V75888 LEB-03-145 2858812-90-3 LEB-03-145 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a C5 alkyl linker.
LEB-03-146 V75887 LEB-03-146 2858812-91-4 LEB-03-146 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a PEG2 linker.
LEB-03-153 V75889 LEB-03-153 2858812-88-9 LEB-03-153 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a linker-free linker.
Myt1-IN-4 V85064 Myt1-IN-4
Myt1-IN-6 V118719 Myt1-IN-6 3056083-14-5 Myt1-IN-6 (compound formula (1)) is a highly selective MYT1 kinase inhibitor.
p38α-IN-9 V142080 p38α-IN-9 2133007-20-0 p38α-IN-9 is a p38α inhibitor with an IC50 value below 20 nM, which can block the enzyme activity of p38α.
PD-166285 V118583 PD-166285 717094-37-6 PD-166285 is a PKMYT1 inhibitor with an IC50 value of 17 nM.
PKMYT1-IN-1 V142801 PKMYT1-IN-1 3033609-83-2 PKMYT1-IN-1 is an inhibitor of membrane-associated tyrosine and threonine kinases (PKMYT1) with an IC50 of 8.8 nM.
PKMYT1-IN-10 V118669 PKMYT1-IN-10 PKMYT1-IN-10 is a selective PKMYT1 inhibitor with an IC50 value of 3 nM.
PKMYT1-IN-11 V114335 PKMYT1-IN-11 3097325-25-9 PKMYT1-IN-11 (Example 1) is a PKMYT1 inhibitor with an IC50 value of 4.49 nM.
PKMYT1-IN-12 V110829 PKMYT1-IN-12 2974454-59-4 PKMYT1-IN-12 (compound 4) is a selective PKMYT1 inhibitor with an IC₅₀ of 2.6 nM.
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