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Src

Src

Src family kinase (SFK) is a family of non-receptor tyrosine kinases including nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily.Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways. Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.

Src related products

Structure Cat No. Product Name CAS No. Product Description
(R)-LW-Srci-8 V88068 (R)-LW-Srci-8 (R)-LW-Srci-8 is a selective covalent inhibitor of c-Src (IC50= 35.83 nM), which can impair the autophosphorylation of c-Src by targeting the autophosphorylation site (Y419) of c-Src kinase.
1-(叔丁基)-3-(萘-1-基)-1H-吡唑并[3,4-d]嘧啶-4-胺 V3629 1-Naphthyl PP1(1-NA-PP1) HCl 956025-47-1 1-Naphthyl PP1 HCl (also known as 1-NA-PP1 hydrochloride) is a novel, potent and selective ATP-competitive inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively.
3-[[4-[(5-羟基-2-甲基苯基)氨基]-2-嘧啶基]氨基]苯甲酰胺 V4777 Lck inhibitor 2 944795-06-6 Lck inhibitor 2, a bis-anilinopyrimidine derivative, is a novel and potent multi-kinase inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK with IC50 values of 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively.
4-氨基-1-叔丁基-3-(1`-萘)吡唑并[3,4-d]嘧啶 V3630 1-Naphthyl PP1(1-NA-PP 1) 221243-82-9 1-Naphthyl PP1 (also known as 1-NA-PP1) is a novel, potent and selective ATP-competitive inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl with IC50 values of 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively.
4-氨基1-叔丁基-3-(1'-萘甲基)吡唑并[3,4-D]嘧啶 V3628 1-NM-PP1 221244-14-0 1-NM-PP1,a C3-modified analog of PP1, is a novel, potent and cell permeable protein kinase D (PKD) inhibitor with anIC50of 0.398 μM.1-NM-PP1 has shown the selective inhibition of protein kinases that have been mutated with the IC50 values of 28 μM, 1.0 μM, 3.4 μM, 29 μM, 24 μM,4.3 nM, 3.2 nM, 120 nM,5 nM and 8 nM for v-Src, c-Fyn, c-Abl, CDK2, CAMKII, v-Src-as1, c-Fyn-as1, cAbl-as2, CDK2-as1 and CAMKII-as1, respectively.
Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA V77786 Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide that binds to the src SH2 domain (IC50≈1 µM).
AG01 V119770 AG01 AG01 is a monoclonal antibody targeting the granule protein precursor (GP88).
AMG-47a V3462 AMG-47a 882663-88-9 AMG-47a is a novel, potent inhibitor of Lck and T cell proliferation which exhibits anti-inflammatory activity with ED50 of 11 mg/kg in the anti-CD3 induced production of IL-2 in mice.
Antiallergic agent-1 V69771 Antiallergic agent-1 2839159-12-3 Antiallergic agent-1 is a Src family kinase inhibitor and may serve as a new valuable lead compound for the discovery of antiallergic active molecules in the future.
Antifibrotic agent 1 V129018 Antifibrotic agent 1 Antifibrotic agent 1 is an orally effective anti-idiopathic pulmonary fibrosis (IPF) drug.
AZM475271 V2984 AZM475271 476159-98-5 AZM475271 is a potent, selective and oral inhibitor of Src kinase with IC50 of 5 nM and with potential anticancer activities; it has no inhibitory activity on Flt3, KDR, Tie-2.
BT424 V69764 BT424 2755180-37-9 BT424 is a specific HCK inhibitor.
Caffeic acid-pYEEIE V69778 Caffeic acid-pYEEIE 507471-72-9 Caffeic acid-pYEEIE is a non-phosphopeptide inhibitor (antagonist) with strong binding affinity to the GST-Lck-SH2 domain.
Caffeic acid-pYEEIE TFA V77175 Caffeic acid-pYEEIE TFA Caffeic acid-pYEEIE TFA is a non-phosphopeptide inhibitor (antagonist) with strong binding affinity to the GST-Lck-SH2 domain.
CGP062464 V131445 CGP062464 121405-24-1 CGP062464 is a c-Src tyrosine kinase inhibitor (IC50: < 50 nM).
CGP77675 hydrate V78736 CGP77675 hydrate CGP77675 hydrate is an orally bioavailable Src family kinase inhibitor.
Cisplatin/Dasatinib prodrug-1 V88070 Cisplatin/Dasatinib prodrug-1 Cisplatin/Dasatinib prodrug-1 (Compound 3) is a prodrug of Cisplatin and Dasatinib.
CSK substrate V88069 CSK substrate CSK substrate is a specific substrate of C-terminal Src kinase (CSK), which can bind to CSK and downregulate the levels of Src family members.
DC-Srci-6649 V69772 DC-Srci-6649 1037545-61-1 DC-Srci-6649 is a c-Src kinase inhibitor that can suppress phosphorylation and locks c-Src in an inactive state.
DFCI-002-06 V108919 DFCI-002-06 3092208-36-8 DFCI-002-06 is an orally effective dual-target HCK/BTK protein degrader with DC₅₀ values of 1.3 nM for HCK and 4.5 nM for BTK.
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