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SHP2

SHP2

A 593 amino acid classical non-receptor protein tyrosine phosphatase (PTP), Src-homology-2-containing protein tyrosine phosphatase 2 (SHP2) is encoded by the PTPN11 gene. SHP2 participates in a number of signaling pathways, including PI3K-AKT, JAK-STAT, RAS-MAPK, and PD-1/PD-L1. Additionally, SHP2 controls mitochondrial homeostasis to negatively regulate the activation of the recombinant NLRP3 (NLR family, pyrin domain containing protein 3) inflammasome. SHP2 has been viewed as a very desirable target for treating human diseases, particularly cancer.

SHP2 related products

Structure Cat No. Product Name CAS No. Product Description
SHP2-IN-17 V69757 SHP2-IN-17 2941498-93-5 SHP2-IN-17 (compound 192) is a SHP2 inhibitor (antagonist) with IC50 of 2 nM.
SHP2-IN-18 V69759 SHP2-IN-18 2941498-87-7 SHP2-IN-18 (compound 183) is a SHP2 inhibitor (antagonist) with IC50 of 3 nM.
SHP2-IN-19 V69749 SHP2-IN-19 2941498-84-4 SHP2-IN-19 (compound 183) is a SHP2 inhibitor (antagonist) with IC50 of 3 nM.
SHP2-IN-20 V69755 SHP2-IN-20 2941498-94-6 SHP2-IN-20 (compound 193) is a SHP2 inhibitor (antagonist) with IC50 of 3 nM.
SHP2-IN-21 V69750 SHP2-IN-21 2941499-08-5 SHP2-IN-21 (compound 208) is a SHP2 inhibitor (antagonist) with IC50 of 3 nM.
SHP2-IN-22 V69756 SHP2-IN-22 2802453-88-7 SHP2-IN-22 is an allosteric inhibitor of SHP2 with IC50 of 17.7 nM.
SHP2-IN-24 V84645 SHP2-IN-24
SHP2-IN-27 V88063 SHP2-IN-27 2376012-00-7 SHP2-IN-27 (compound 28) is an allosteric inhibitor of tyrosine phosphatase SH2.
SHP2-IN-28 V88065 SHP2-IN-28 SHP2-IN-28 (Compound 7188-0011) is an inhibitor of Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) (IC50=54.31 μM).
SHP2-IN-31 V99649 SHP2-IN-31 2411321-35-0 SHP2-IN-31 is a SHP2 inhibitor with IC50 of 13 nM (wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K).
SHP2-IN-32 V97081 SHP2-IN-32 3043685-80-6 SHP2-IN-32 (Compound C6) is an orally available allosteric SHP2 inhibitor with IC50 of 0.13 nM.
SHP2-IN-33 V104461 SHP2-IN-33 2894017-46-8 SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with IC50 of 1.2 μM for SHP2.
SHP2-IN-34 V104863 SHP2-IN-34 2924065-12-1 SHP2-IN-34 (Compound A8) is a phenylurea SHP2 inhibitor with anticancer activity.
SHP2-IN-5 V69744 SHP2-IN-5 54755-93-0 SHP2-IN-5 (compound 1) is a SHP2 inhibitor (IC50= 97 nM).
SHP2-IN-6 V51177 SHP2-IN-6 2169223-48-5 SHP2 inhibitor
SHP2-IN-6 HCl V51178 SHP2-IN-6 HCl 2169223-49-6 SHP2 inhibitor
SHP844 V69752 SHP844 2222280-82-0 SHP844 is a SHP2 inhibitor (antagonist) with IC50 of 18.9 µM.
Suchilactone (Jatrophan) V84772 Suchilactone (Jatrophan) 50816-74-5
TK-642 V88062 TK-642 2765183-10-4 TK-642 is a highly active, selective, orally active allosteric SHP2 inhibitor based on pyrazolopyrazine (IC50=2.7 nmol/L).
YF704 V80061 YF704 2956716-97-3 YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM).
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