A 593 amino acid classical non-receptor protein tyrosine phosphatase (PTP), Src-homology-2-containing protein tyrosine phosphatase 2 (SHP2) is encoded by the PTPN11 gene. SHP2 participates in a number of signaling pathways, including PI3K-AKT, JAK-STAT, RAS-MAPK, and PD-1/PD-L1. Additionally, SHP2 controls mitochondrial homeostasis to negatively regulate the activation of the recombinant NLRP3 (NLR family, pyrin domain containing protein 3) inflammasome. SHP2 has been viewed as a very desirable target for treating human diseases, particularly cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V69755 | SHP2-IN-20 | 2941498-94-6 | SHP2-IN-20 (compound 193) is a SHP2 inhibitor (antagonist) with IC50 of 3 nM. |
|
V69750 | SHP2-IN-21 | 2941499-08-5 | SHP2-IN-21 (compound 208) is a SHP2 inhibitor (antagonist) with IC50 of 3 nM. |
|
V69756 | SHP2-IN-22 | 2802453-88-7 | SHP2-IN-22 is an allosteric inhibitor of SHP2 with IC50 of 17.7 nM. |
|
V69744 | SHP2-IN-5 | 54755-93-0 | SHP2-IN-5 (compound 1) is a SHP2 inhibitor (IC50= 97 nM). |
|
V51177 | SHP2-IN-6 | 2169223-48-5 | SHP2 inhibitor |
|
V51178 | SHP2-IN-6 HCl | 2169223-49-6 | SHP2 inhibitor |
|
V69752 | SHP844 | 2222280-82-0 | SHP844 is a SHP2 inhibitor (antagonist) with IC50 of 18.9 µM. |
|
V80061 | YF704 | YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM). |
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