FGFR (Fibroblast growth factor receptors) are the receptors that bind to members of the fibroblast growth factor family of proteins.Pathological conditions involve some of these receptors. Achondroplasia can be brought on by a point mutation in FGFR3. Vertebrates have been found to contain five distinct membrane FGFRs, all of which are members of the tyrosine kinase superfamily (FGFR1, FGFR2, FGFR3, FGFR4, FGFR6). One of the most significant families of paracrine factors that function in the development process is the fibroblast growth factor family. They control which cells differentiate into mesoderm, the production of blood vessels, the growth of limbs, and the growth and differentiation of many different cell types.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V79410 | FGFR1 inhibitor-8 | FGFR1 inhibitor-8 (Compound 9) is an FGFR1 inhibitor (IC50s: 0.5 nM). | |
|
V79411 | FGFR1 inhibitor-9 | FGFR1 inhibitor-9 (Compound 9) is an FGFR1 inhibitor (IC50s: 0.85 nM). | |
|
V31345 | FGFR1/DDR2 inhibitor 1 | 2308497-58-5 | FGFR1/DDR2 inhibitor 1 (compound 11k) is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively. |
|
V79412 | FGFR1/VEGFR2-IN-1 | FGFR1/VEGFR2-IN-1 (compound 2b) is an FGFR1/VEGFR2 inhibitor. | |
|
V69475 | FGFR2-IN-1 | 2677709-76-9 | FGFR2-IN-1 is a selective FGFR2 inhibitor (antagonist) with IC50 of 140 nM. |
|
V69469 | FGFR2-IN-2 | 2677709-81-6 | FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor (antagonist) with IC50s of 389, 29 and 758 nM for FGFR1, FGFR2 and FGFR3 respectively. |
|
V69472 | FGFR2/3-IN-1 | 2640352-86-7 | FGFR2/3-IN-1 is a potent and specific inhibitor of FGFR2 and FGFR3 (FGFR) with IC50 of 1 nM and 0.5 nM, respectively. |
|
V69483 | FGFR3-IN-4 | 2833706-13-9 | FGFR3-IN-4 is a selective FGFR3 inhibitor (antagonist) with IC50 of less than 50 nM. |
|
V69470 | FGFR3-IN-5 | 2446664-72-6 | FGFR3-IN-5 is a potent and specific FGFR3 inhibitor (antagonist) with IC50s of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. |
|
V69478 | FGFR3-IN-6 | 2833703-72-1 | FGFR3-IN-6 is a potent selective inhibitor of FGFR3 with IC50 of less than 350 nM. |
|
V69479 | FGFR3-IN-7 | 2833703-79-8 | FGFR3-IN-7 is a potent selective inhibitor of FGFR3 with IC50 of less than 350 nM. |
|
V21016 | FGFR4-IN-1 | 1708971-72-5 | FGFR4-IN-1 is a potent FGFR4 inhibitor (antagonist) with IC50 of 0.7 nM. |
|
V69484 | FGFR4-IN-10 | 2857862-25-8 | FGFR4-IN-10 (compound 5a) is a potent and specific FGFR4 inhibitor (antagonist) with IC50 of 70.7 nM. |
|
V78610 | FGFR4-IN-14 | FGFR4-IN-14 (Compound 27i) is an FGFR4 inhibitor (IC50= 2.4 nM). | |
|
V69457 | FGFR4-IN-16 | 1970120-44-5 | FGFR4-IN-16 (CY-15-2) is a covalent/irreversible inhibitor of FGFR-4 and may be utilized in cancer-related research. |
|
V69476 | FGFR4-IN-5 | 1628793-01-0 | FGFR4-IN-5 is a potent and specific covalent FGFR4 inhibitor (antagonist) with IC50 of 6.5 nM. |
|
V69462 | FGFR4-IN-6 | 2760970-10-1 | FGFR4-IN-6 (Compound 9ka) is a covalent and reversible FGFR4 inhibitor (antagonist) with IC50 of 5.4 nM. |
|
V69459 | FGFR4-IN-7 | 2765046-07-7 | FGFR4-IN-7 (Compound C3) is a covalent and reversible FGFR4 inhibitor (antagonist) with IC50 of 0.42 μM. |
|
V69461 | FGFR4-IN-8 | 2765240-52-4 | FGFR4-IN-8 (Compound 7v) is an ATP-competitive, selective covalent inhibitor of wild-type and mutant FGFR4. |
|
V0615 | FIIN-2 | 1633044-56-0 | FIIN-2 (FIIN 2; FIIN2) is a novel irreversible/covalent pan-FGFR inhibitor with potential anticancer activity. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
