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HIV Protease

HIV Protease

HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus.In order to create the mature protein components of an infectious HIV virion, HIV protease cleaves newly synthesized polyproteins at the proper locations. When developing anti-retroviral medications to treat HIV/AIDS (acquired immune deficiency syndrome), HIV protease is a crucial drug target.

HIV-1 protease breaks down the polyproteins Gag and Gag-Pro-Pol to allow viral maturation. More than 12 different substrates are recognized and broken down, which causes viral maturation. Similar to HIV-1, HIV-2 protease is a homodimeric aspartyl enzyme that plays a crucial part in the HIV life cycle by processing the precursor polyproteins Gag and Gag-Pro-Pol, which results in viral maturation.

HIV Protease related products

Structure Cat No. Product Name CAS No. Product Description
20(21)-脱氢赤芝酸A V53394 20(21)-Dehydrolucidenic acid A 852936-69-7 20(21)-Dehydrolucidenic acid A is a triterpene extracted from the fruiting body of the fungus Ganoderma lucidum.
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid V73172 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid 176983-21-4 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is a natural ursane-type triterpene and an effective HIV protease (HIV Protease) inhibitor.
AG-1284 V116284 AG-1284 162054-18-4 AG-1284 is an HIV protease inhibitor with an EC50 value of 0.5 mg/mL.
Desthiazolylmethyl ritonavir V103134 Desthiazolylmethyl ritonavir 256328-82-2 Desthiazolylmethylritonavir is a base-catalyzed degradation product of the HIV protease inhibitor ritonavir.
DMP-851 V115910 DMP-851 188978-02-1 DMP-851 is a cyclic urea-based HIV protease inhibitor with a Ki value of 0.021 nM.
Elunonavir V99711 Elunonavir 2242428-57-3 Elunavir (GS-1156) is an HIV protease inhibitor with a high barrier to resistance and excellent metabolic stability.
Ganomycin I V56034 Ganomycin I 1191255-15-8 Ganomycin I is a dual (bifunctional) inhibitor of α-glucosidase and HMG-CoA reductase.
GRL-07524 V136937 GRL-07524 GRL-07524 is a potent HIV-1 protease inhibitor (Ki = 0.22 nM).
GS-9770 V88269 GS-9770 2306328-43-6 GS-9770 is an orally available HIV protease inhibitor with a Ki of 0.16 nM.
HIV Protease Substrate 1 TFA V79791 HIV Protease Substrate 1 TFA HIV Protease Substrate 1 TFA is an exogenous HIV protease substrate that may be utilized to study the enzymatic activity of HIV protease.
HIV-1 Protease V119248 HIV-1 Protease HIV-1 protease is synthesized as part of a large Gag-Pol precursor protein.
HIV-1 protease-IN-13 V83408 HIV-1 protease-IN-13
HIV-1 protease-IN-14 V137392 HIV-1 protease-IN-14 HIV-1 protease-IN-14 is a potent HIV-1 protease inhibitor with Ki values of 0.28 nM for wild-type HIV-1 protease and 56.9 nM for R41T mutant HIV-1 protease.
HIV-1 protease-IN-3 V79794 HIV-1 protease-IN-3 HIV-1 protease-IN-3 (compound 14) is a potent HIV-1 protease inhibitor (IC50=71 nM; EC50=0.86 μM).
HIV-1 protease-IN-6 V73171 HIV-1 protease-IN-6 2892016-32-7 HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor (antagonist) with IC50 of 21 pM and a Ki of 4.7 pM.
HIV-1 protease-IN-7 V73170 HIV-1 protease-IN-7 2916441-36-4 HIV-1 protease-IN-7 (compound 16) is an orally bioactive HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM).
HIV-1-IN-88 V114750 HIV-1-IN-88 2459707-59-4 V-1-IN-88 (compound 20a) is a potent HIV-1 protease inhibitor (IC50 = 10 pM) with an antiviral EC50 value of 10.4 nM.
HIV-1-IN-91 V112145 HIV-1-IN-91 HIV-1-IN-91 (compound BAN) is an HIV-1 protease inhibitor.
Hydroxy darunavir V137676 Hydroxy darunavir 1130635-75-4 Hydroxy darunavir is a metabolite of darunavir, an HIV-1 protease inhibitor.
Longipedunin A V88270 Longipedunin A 886441-72-1 Longipedunin A is a HIV-1 protease inhibitor with an IC50 value of 50 µg/mL.
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