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DPP-4

DPP-4

Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis.The DPP-IV family of dipeptidyl peptidases, which also includes DPP-7, DPP-8, DPP-9, fibroblast activation protein, and others, cleaves the peptide bond after the penultimate proline residue and has a large number of drug targets.

A serine protease known as DPP-IV (DPP4 or CD26) has been found on a number of immune cells and epithelial cells from different organs. A catalytically active soluble form of the enzyme is also found in several bodily fluids in addition to the membrane-bound enzyme. The N-termini of numerous chemokines, neuropeptides, and hormones are cleaved off by both variants, releasing dipeptides. By focusing on various substrates, DPP IV is essential for the regulation of the immune system, inflammation, oxidative stress, cell adhesion, and apoptosis. Drugs that inhibit DPP IV are frequently used to lower blood sugar.

DPP8 and DPP9 exhibit DPPIV-like activity and have a high degree of sequence similarity. Intracellular N-terminal dipeptidyl peptidases DPP8 and DPP9 (preferentially postproline) have been linked to pathophysiological roles in cancer biology and immune response.

DPP-4 related products

Structure Cat No. Product Name CAS No. Product Description
5-Hydroxy saxagliptin-13C,d2-2 hydrochloride V110707 5-Hydroxy saxagliptin-13C,d2-2 hydrochloride 1572922-53-2 5-Hydroxysaxagliptin-13C,d2-2 hydrochloride is 13C-labeled deuterated 5-hydroxysaxagliptin hydrochloride.
D-γ-Glu-Tyr V108968 D-γ-Glu-Tyr 2417507-97-0 D-γ-Glu-Tyr is a D-isomer of γ-Glu-Tyr, and the two differ only in the type of γ-Glu.
DPP-4-IN-17 V119404 DPP-4-IN-17 DPP-4-IN-17 is an orally effective selective dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC50 of 0.12 nM.
DPP-4-IN-18 V111791 DPP-4-IN-18 486460-31-5 DPP-4-IN-18 (sitagliptin impurity 3) (compound 4) is a highly potent, selective, and orally effective DPP-4 inhibitor with an IC50 value of 27 nM.
DPP9-IN-2 V113234 DPP9-IN-2 3020859-44-0 DPP9-IN-2 is a highly selective, orally effective dipeptidyl peptidase 9 (DPP9) inhibitor with an IC50 value of 12.9 nM.
Gemigliptin hydrochloride V116419 Gemigliptin hydrochloride 1523530-62-2 Gemigliptin hydrochloride is the hydrochloride salt of gemigliptin.
Gemigliptin tartrate hydrate V120126 Gemigliptin tartrate hydrate 1375415-82-9 Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, competitive dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC50 value of 10.3 nM against human recombinant DPP-4.
Gosogliptin hydrochloride V117057 Gosogliptin hydrochloride 869490-47-1 Gogliptin hydrochloride is the hydrochloride salt of gogliptin.
Hypoglycemic agent 4 V110509 Hypoglycemic agent 4 Hypoglycemic agent 4 (compound 5b) is a tetrahydroacridine derivative with oral hypoglycemic activity.
Invobenitug V119526 Invobenitug 3034173-09-3 Invobenitug is a humanized IgG1κ antibody that targets DPP3, with a corresponding isotype control being the human IgG1 kappa isotype control.
MK-0626 V111748 MK-0626 690257-74-0 MK-0626 is a selective, orally active DPP-4 inhibitor with an IC50 of 6.3 nM.
Saxagliptin hydrate V2633 Saxagliptin hydrate 945667-22-1 Saxagliptin hydrate (also known as BMS-477118 hydrate, Onglyza hydrate, BMS 477118 hydrate, BMS477118 hydrate; brand name: Onglyza), the hydrate form of Saxagliptin, is a potent,orally bioactive, selective and reversible DPP4 (dipeptidyl peptidase-4) inhibitor with IC50 of 26 nM.
Sitagliptin hydrochloride V115655 Sitagliptin hydrochloride 486459-71-6 Sitagliptin hydrochloride (MK-0431) is an orally effective and highly selective DPP-4 inhibitor with an IC50 value of 19 nM.
TAK-100 V116042 TAK-100 907609-33-0 TAK-100 is a selective, orally administered active dipeptidyl peptidase IV (DPP-4) inhibitor with an IC50 value of 5.3 nM.
Talabostat mesylate V15698 Talabostat mesylate 150080-09-4 Talabostat mesylate, the mesylate salt of Talabostat (PT-100; PT100 Val-boroPro), is an orally available inhibitor of dipeptidyl peptidase (DPP4, DPP8, and DPP9) with a Ki of 0.18 nM.
ZY15557 V110989 ZY15557 1601480-12-9 ZY15557 is a novel, competitive, long-acting, orally active DPP-4 inhibitor with a Ki value of 5.53 nM.
利拉利汀 V0742 Linagliptin 668270-12-0 Linagliptin (formerly known as BI-1356; trade names Tradjenta and Trajenta)is a xanthine-based, highly potent, selective, andcompetitive DPP-4 inhibitor with potential anti-diabetic activity.
嘌罗霉素;博罗霉素 V5081 Puromycin Aminonucleoside (NSC-3056) 58-60-6 Puromycin aminonucleoside (formerly known as NSC 3056; PAN, NSC-3056), the aminonucleoside portion of the antibiotic puromycin, is commonly used in nephrosis animal models as well as in the study of human glomerular disease, and glomerular function and morphology.
奥格列汀 V2771 Omarigliptin 1226781-44-7 Omarigliptin (formerly known as MK-3102; MK3102) is a potent, selective, oral and long-acting inhibitor ofDPP-4 (dipeptidyl peptidase 4) with antidiabetic effects.
安奈格列汀 V4104 Anagliptin (SK-0403) 739366-20-2 Anagliptin (formerly known as SK0403) is a novel, potent, orally bioactive, highly selective inhibitor of DPP-4 (dipeptidyl peptidase 4)with anIC50of 3.8 nM.
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