Deubiquitinases (DUBs) are a family of proteases whose function is to cleave ubiquitin (Ub) or ubiquitin-like proteins from proproteins or ubiquitin(s) conjugated with target substrate.According to their enzymatic cleavage method, DUBs can be classified into two primary classes: zinc metalloproteases and cysteine proteases. These include Jab1/Mov34/Mpr1 (JAMM) metalloproteases, ovarian tumor proteases, Machado-Joseph disease proteases, ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), and novel DUB family, (MINDY) proteases that contain MIU.
A significant post-translational alteration known as ubiquitination is essential for several crucial biological processes. A coordinated action of the E1, E2, and E3 enzymes results in the attachment of ubiquitin to a substrate protein in this process, and DUBs remove it. DUBs are crucial Ub system regulators because they control a wide range of cellular functions, such as protein sorting, trafficking, and turnover. Alterations in DUB activity have been linked to a wide range of diseases, including cancer. DUBs are fresh options for the creation of drugs that are target-directed.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V56174 | N-Ethylmaleimide-d5 (NEM-d5) | 360768-37-2 | N-Ethylmaleimide-d5 is the deuterated form of N-Ethylmaleimide. |
|
V41058 | OTUB1/USP8-IN-1 | 2858800-98-1 | OTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor (antagonist) with IC50s of 0.17 and 0.28 nM for OTUB1 and USP8 inhibition, respectively. |
|
V35255 | STAMBP-IN-1 | 896683-78-6 | STAMBP-IN-1 is a small molecule inhibitor of STAMBP deubiquitinase that can interrupt the STAMBP-Ub-NALP7 interaction. |
|
V51243 | USP1-IN-3 | 2821749-58-8 | USP1 inhibitor |
|
V35154 | USP1-IN-4 | 2878441-72-4 | USP1-IN-4 (compound 10) is a USP1 inhibitor (antagonist) with IC50 of 2.44 nM. |
|
V54457 | USP1-IN-5 | 2925547-94-8 | USP1-IN-5 (compound 10) is a USP1 inhibitor (IC50<50 nM). |
|
V54458 | USP1-IN-6 | 2925547-95-9 | USP1-IN-6 (compound 11) is a USP1 inhibitor (IC50<50 nM). |
|
V51241 | Usp22i-S02 | 309735-96-4 | USP22 inhibitor |
|
V35153 | USP28-IN-2 | 2931509-11-2 | USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity for USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. |
|
V35152 | USP28-IN-3 | 2931509-14-5 | USP28-IN-3 is a USP28 inhibitor (IC50=0.1 μM) with high selectivity for USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. |
|
V35151 | USP28-IN-4 | 2931509-15-6 | USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with better selectivity for USP28 than USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. |
|
V54459 | USP5-IN-1 | 2851040-81-6 | USP5-IN-1 (compound 64) is a potent inhibitor of the deubiquitinase USP5, binding to USP5 ZnF UBD with a KD of 2.8 μM. |
|
V51248 | USP7-IN-10 | 2755995-01-6 | USP7-IN-10 (compound 1) is a potent ubiquitin protein-specific proteinase 7 USP7 inhibitor (antagonist) with IC50 of 13.39 nM. |
|
V76383 | USP7-IN-10 hydrochloride | USP7-IN-10 HCl (compound 1) is a potent ubiquitin protein-specific proteinase 7 USP7 inhibitor (antagonist) with IC50 of 13.39 nM. | |
|
V51245 | USP7-IN-11 | 2763872-32-6 | USP7 (Deubiquitinase) inhibitor |
|
V35150 | USP7-IN-12 | 2763698-01-5 | USP7-IN-12 (compound 1) is a potent and orally bioactive Usp7 inhibitor (antagonist) with IC50 of 3.67 nM. |
|
V51244 | USP7-IN-7 | 2413944-70-2 | USP7 inhibitor |
|
V51246 | USP8-IN-2 | 2477651-11-7 | USP8 inhibitor |
|
V51247 | USP8-IN-3 | 2477651-10-6 | deubiquitinase USP8 inhibitor |
|
V51253 | Vialinin A (Terrestrin A) | 858134-23-3 | inhibitor of TNF-α, USP4/5 |
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