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Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis.A variety of antiviral products are among them; they are used to stop viral replication in infected cells. Nucleoside analogues can be used to treat HIV, herpes simplex, hepatitis B, and hepatitis C. Once phosphorylated, they function as antimetabolites by resembling nucleotides closely enough to be incorporated into developing DNA strands.Chemotherapy agents, such as gemcitabine and 5-FU, are used to treat cancer using less selective nucleoside analogues. A metabolite, a different chemical that is produced as part of normal metabolism, can't be used when an antimetabolite is present. These substances frequently share structural similarities with the metabolite that they disrupt, such as the antifolates that prevent the absorption of folic acid. Antimetabolites are used as chemotherapy for cancer because their presence can have toxic effects on cells, such as halting cell growth and cell division.

Nucleoside Antimetabolite/Analog related products

Structure Cat No. Product Name CAS No. Product Description
V55914 2'-Chloro-N6-(3-methoxy)benzyl adenosine 722504-73-6 2'-Chloro-N6-(3-methoxy)benzyl adenosine is an analogue of purine nucleoside.
V55286 2'-Chloro-N6-(4-methoxy)benzyl adenosine 722504-77-0 2'-Chloro-N6-(4-methoxy)benzyl adenosine is an analogue of purine nucleoside.
V55295 2'-Chloro-N6-(4-trifluoromethyl)benzyl adenosine 722515-03-9 2'-Chloro-N6-(4-trifluoromethyl)benzyl adenosine is an analogue of purine nucleoside.
V55463 2'-Chloro-N6-benzyl adenosine 23558-62-5 2'-Chloro-N6-benzyl adenosine is an adenine nucleoside analog.
V55647 2'-Chlorothymidine 54898-34-9 2'-Chlorothymidine is a thymidine analog.
V55399 2'-Deoxy-2'-(N-trifluoroacetyl)amino-5'-O-DMTr-uridine 3'-CED phosphoramidite 126139-44-4 2'-Deoxy-2'-(N-trifluoroacetyl)amino-5'-O-DMTr-uridine 3'-CED phosphoramidite is a uridine nucleoside analogue.
V55324 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine 139878-36-7 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine is an analogue of purine nucleoside.
V75607 2′-Deoxy-2′-fluoro-3-deaza-arabinouridine 2095417-48-2 2′-Deoxy-2′-fluoro-3-deaza-arabinouridine is an analogue of purine nucleoside.
V75910 2'-Deoxy-2'-fluoro-4'-thio-β-D-arabinouridine 941610-00-0 2'-Deoxy-2'-fluoro-4'-thio-β-D-arabinouridine is an analogue of purine nucleoside.
V55781 2′-Deoxy-2′-fluoro-4-deoxy-arabinouridine 136675-88-2 2′-Deoxy-2′-fluoro-4-deoxy-arabinouridine is an analogue of purine nucleoside.
V55692 2'-Deoxy-2'-fluoro-4-thio-beta-D-arabinouridine 892145-76-5 2'-Deoxy-2'-fluoro-4-thio-beta-D-arabinouridine is an analogue of purine nucleoside.
V55941 2'-Deoxy-2'-fluoro-4-thiouridine 10212-16-5 2'-Deoxy-2'-fluoro-4-thiouridine is an analogue of purine nucleoside.
V75625 2'-Deoxy-2'-fluoro-5-hydroxymethyl arabinouridine 94817-51-3 2'-Deoxy-2'-fluoro-5-hydroxymethyl arabinouridine is a thymidine analog.
V53113 2'-Deoxy-2'-fluoro-5-iodouridine (FIRU) 55612-21-0 2'-Deoxy-2'-fluoro-5-iodouridine is an analogue of purine nucleoside.
V55503 2′-Deoxy-2′-fluoro-5-methoxy-arabinouridine 2305415-76-1 2′-Deoxy-2′-fluoro-5-methoxy-arabinouridine is a uridine analog.
V55587 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-aD-arabino uridine 294868-24-9 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-aD-arabino uridine is an analogue of purine nucleoside.
V75514 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-β-D-arabino uridine 135123-34-1 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-β-D-arabino uridine is an analogue of purine nucleoside.
V55947 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine 78636-53-0 2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine is a cytosine nucleoside analog.
V55352 2'-Deoxy-2'-fluoro-5-methylcytidine 182495-80-3 2'-Deoxy-2'-fluoro-5-methylcytidine is a cytosine nucleoside analog.
V56018 2'-Deoxy-2'-fluoro-5-trifluoromethyl-arabinouridine 114652-80-1 2′-Deoxy-2′-fluoro-5-triflu oromethyl-arabinouridine is a thymidine analog.
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