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p53

p53

p53 related products

Structure Cat No. Product Name CAS No. Product Description
1-吖丁啶硫代羧酸[1-(2-吡啶基)亚乙基]酰肼 V0017 NSC 319726 71555-25-4 NSC319726 is a novel and potent p53(R175) mutant reactivator with with potential anticancer activity.
2-苯乙炔磺酰胺 V0020 Pifithrin-μ (NSC-303580) 64984-31-2 Pifithrin-μ (NSC303580) is a novel and potent inhibitor of p53 binding and p53-mediated apoptosis with a Kd of 0.82 mM in vitro.
4-异硫脲基丁腈盐酸盐 V4115 Kevetrin HCl 66592-89-0 Kevetrinhydrochloride (also known as thioureidobutyronitrile; 4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride), is a water-soluble, small molecule activator of the tumor suppressor protein p53.
Anticancer agent 68 V76056 Anticancer agent 68 2692652-36-9 Anticancer agent 68 is (Compound 12) is an anticancer agent.
Apoptosis inducer 56 V129295 Apoptosis inducer 56 952306-31-9 Apoptosis inducer 56 is an apoptosis inducer.
CDK2/MDM2-IN-1 V88505 CDK2/MDM2-IN-1 CDK2/MDM2-IN-1 (III-13) is a CDK2/MDM2 dual inhibitor with IC50 of 2.60 nM for CDK2.
CK2-TN03 V131849 CK2-TN03 313226-24-3 CK2-TN03 is an ATP-competitive casein kinase 2 (CK2) inhibitor with an IC50 of 165 nM and a Ki of 20 nM.
COTI-2 V3174 COTI-2 1039455-84-9 COTI-2 is an orally available, 3rd generation small molecule activator of the mutant p53 protein (a tumor suppressor).
MI773 (SAR-405838) V0021 MI-773 (2'S,3R isomer, SAR-405838) 1303607-60-4 MI-773 (2S,3R isomer, SAR405838) is a novel, potent, specific and orally bioavailable small molecule antagonist of MDM2/piro-oxindole HDM2 (Murine double minute 2/human double minute 2) with a Ki value of 0.88 nM.
MS78 V80841 MS78 MS78 is an acetylation-targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein.
N-[[[4-(乙酰氨基)苯基]氨基]硫代甲酰]-4-叔丁基苯甲酰胺 V0016 Tenovin-1 380315-80-0 Tenovin-1, a small molecule compound discovered by a cell-based screen, is a novel and potent activator of p53 that protects against MDM2-mediated p53 degradation.
NSC-59984 V0018 NSC59984 803647-40-7 NSC59984 is a novel and potent activator of p53 with potential anticancer activity.
NVP-CFC218 V141720 NVP-CFC218 1313363-06-2 NVP-CFC218 is a selective TP53-MDM2 inhibitor with similar structure and biochemical properties to NVP-CGM097 (IC50 of 1.6 nM: displacing p53 peptide from the surface of HDM2).
PNC-27 acetate V88518 PNC-27 acetate PNC-27 acetate is a chimeric p53-penetrating peptide that binds to HDM-2 in a p53 peptide-like structure, inducing selective membrane pore formation and leading to cancer cell lysis.
Rezatapopt analog-2 V144061 Rezatapopt analog-2 2636847-09-9 Rezatapopt analog-2 is an analogue of Rezatapopt that can be combined with P53.
RITA (NSC-652287) V0015 RITA (NSC 652287) 213261-59-7 RITA (also known as NSC-652287) is a novel and potent inhibitor of p53-HDM-2 protein-protein interaction with potential anticancer activity.
SCH529074 V12467 SCH529074 922150-11-6 SCH529074 is an orally bioactive p53 activator.
Seldegamadlin (KT-253) V105065 Seldegamadlin (KT-253) 2713618-08-5 KT-253 is a p53 stabilizer and PROTAC degrader of MDM2 (DC50=0.4 nM).
SEN205A V144772 SEN205A 958712-85-1 SEN205A is a fragment compound that can bind to the hydrophobic pocket (Kd = 0.5-1.0 mM) of human S100B, which is a key region for the interaction of S100B with TRTK-12 and p53. SEN205A can be displaced from this site by TRTK-12.
Siremadlin succinate V144971 Siremadlin succinate 1638193-48-2 Siremadlin succinate is an MDM2 inhibitor and cell cycle regulator.
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