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SHP2

SHP2

SHP2 related products

Structure Cat No. Product Name CAS No. Product Description
NSC-87877 disodium V51367 NSC-87877 disodium 56932-43-5 SHP-1 and SHP-2 PTP inhibitor
PF-03622905 V41014 PF-03622905 1072100-15-2 PF-03622905 is a potent ATP-competitive PKC inhibitor (antagonist) with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ and PKCθ, respectively.
SHP099 V3045 SHP099 1801747-42-1 SHP099 (SHP-099), identified through HTS and structure-based drug design, is a potent, selective, orally bioavailable, and highly efficacious allosteric inhibitor of SHP2 [Src homology-2 domain containing protein tyrosine phosphatase-2] with anticancer and anti-osteoarthritis activity.
SHP2 ATTEC degrader-1 V144852 SHP2 ATTEC degrader-1 SHP2 ATTEC degrader-1 is an SHP2 ATTEC degrader.
SHP2 protein degrader-3 V144853 SHP2 protein degrader-3 SHP2 protein degrader-3 is an SHP2 AUTAC degrader.
SHP2-IN-13 V69762 SHP2-IN-13 2951854-02-5 SHP2-IN-13 is a selective and orally bioactive SHP2 “tunnel site” allosteric inhibitor (antagonist) with IC50 of 83.0 nM.
SHP2-IN-20 V69755 SHP2-IN-20 2941498-94-6 SHP2-IN-20 (compound 193) is a SHP2 inhibitor (antagonist) with IC50 of 3 nM.
SHP2-IN-30 V144854 SHP2-IN-30 SHP2-IN-30 is an allosteric SHP2 inhibitor with an IC50 value of 104 nM.
SHP2-IN-33 V104461 SHP2-IN-33 2894017-46-8 SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with IC50 of 1.2 μM for SHP2.
SHP2-IN-36 V144856 SHP2-IN-36 SHP2-IN-36 is an allosteric inhibitor of SHP2 with an IC50 value of 9.0 nM.
SHP2-IN-37 V144857 SHP2-IN-37 3086289-71-3 SHP2-IN-37 is a highly effective and selective SHP2 allosteric inhibitor with an IC50 value of 0.023 μM.
SHP2-IN-39 V144859 SHP2-IN-39 1801764-98-6 SHP2-IN-39 is an inhibitor of SHP2 with an IC50 of 0.007 μM.
SHP2-IN-40 V144860 SHP2-IN-40 2056002-39-0 SHP2-IN-40 is an inhibitor of SHP2 with an AC50 of 0.0107 μM.
SHP2-IN-41 V144861 SHP2-IN-41 3081261-84-6 SHP2-IN-41 is an SHP2 inhibitor with an IC50 value of less than 0.1 μM.
SHP2-IN-43 V120153 SHP2-IN-43 2458219-45-7 SHP2-IN-43 (compound 5) is an SHP2 inhibitor with an IC50 of 98.7 nM.
SHP2-IN-46 V144862 SHP2-IN-46 3086360-36-0 SHP2-IN-46 is an orally effective SHP2 inhibitor (IC50 = 11.76 μM).
TK-684 V146145 TK-684 TK-684 is a highly effective and selective SHP2 allosteric inhibitor with IC50 values of 2.1 nM for SHP2WT and >1000 nM for SHP22PTP.
TK-685 V146146 TK-685 TK-685 is an orally effective selective allosteric SHP2 inhibitor with an IC50 of 2.1 nM.
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