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FGFR

FGFR

FGFR related products

Structure Cat No. Product Name CAS No. Product Description
Aprutumab ixadotin V129308 Aprutumab ixadotin 1708947-48-1 Aprutumab ixadotin is the first antibody-drug conjugate (ADC) targeting FGFR2, and also the first ADC to use an Auristatin-based payload.
BLU-554(BLU-554) V2693 BLU-554(BLU-554) 1707289-21-1 BLU-554 is a novel potent, highly-selective, and orally bioavailable inhibitor of FGFR4 (fibroblast growth factor receptor 4) with an IC50 value of 5 nM in cell free assays.
BLU9931 V0617 BLU9931 1538604-68-0 BLU9931 (BLU-9931; BLU 9931) is an irreversible and selective FGFR4 inhibitor with potential anticancer activity.
CPL304110 V69468 CPL304110 1627826-19-0 CPL304110 is a potent, orally bioavailable, and selective inhibitor of the fibroblast growth factor receptor FGFR (1-3) with IC50s of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3).
Efruxifermin V69485 Efruxifermin 2375240-92-7 Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to modified human FGF21).
Fexagratinib (AZD4547; ADSK091) V0616 Fexagratinib (AZD-4547; ADSK-091) 1035270-39-3 AZD4547 (AZD-4547; AZD 4547) is a novel and orally bioavailable FGFR (fibroblast growth factor receptor) inhibitor with potential antineoplastic activity.
FGFR-IN-23 V118276 FGFR-IN-23 FGFR-IN-23 (compound 9p) is a covalent pan-FGFR inhibitor with IC50 values of 14 nM, 4.2 nM, 5 nM and 220 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
FGFR-IN-26 V135928 FGFR-IN-26 2823290-68-0 FGFR-IN-26 is an orally effective FGFR inhibitor.
FGFR1 inhibitor-2 V69471 FGFR1 inhibitor-2 2410612-08-5 FGFR1 inhibitor-2 is an FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells).
FGFR3-IN-11 V135919 FGFR3-IN-11 FGFR3-IN-11 is a fibroblast growth factor receptor 3 (FGFR3) inhibitor with a Ka value of 4.8 μM.
FGFR3-IN-6 V69478 FGFR3-IN-6 2833703-72-1 FGFR3-IN-6 is a potent selective inhibitor of FGFR3 with IC50 of less than 350 nM.
FGFR3-IN-7 V69479 FGFR3-IN-7 2833703-79-8 FGFR3-IN-7 is a potent selective inhibitor of FGFR3 with IC50 of less than 350 nM.
FGFR3-IN-9 V88045 FGFR3-IN-9 2446523-17-5 FGFR3-IN-9 (example27) is a selective FGFR3 inhibitor.
FGFR4-IN-1 V21016 FGFR4-IN-1 1708971-72-5 FGFR4-IN-1 is a potent FGFR4 inhibitor (antagonist) with IC50 of 0.7 nM.
FGFR4-IN-20 V88034 FGFR4-IN-20 FGFR4-IN-20 (comp 11) is an orally active and selective FGFR4 inhibitor with IC50s of 19 and 36 nM for Huh7 cell and FGFR4 enzyme inhibition.
FGFR4-IN-22 V105231 FGFR4-IN-22 2922812-74-4 FGFR4-IN-22 (Compound 10f) is a potent inhibitor of FGFR4 with IC50 of 5.4 nM.
FGFR4-IN-5 V69476 FGFR4-IN-5 1628793-01-0 FGFR4-IN-5 is a potent and specific covalent FGFR4 inhibitor (antagonist) with IC50 of 6.5 nM.
FIIN-2 V0615 FIIN-2 1633044-56-0 FIIN-2 (FIIN 2; FIIN2) is a novel irreversible/covalent pan-FGFR inhibitor with potential anticancer activity.
H3B-6527 V3131 H3B-6527 1702259-66-2 H3B-6527 is a potent, highly selective, orally bioavailable, covalent FGFR4 inhibitor with IC50 value of ~1.2 nM.
HuGAL-F2 V137629 HuGAL-F2 HuGAL-F2 is a human antibody expressed in CHO cells that targets FGF2.
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