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    NSC59984
    NSC59984

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0018
    CAS #: 803647-40-7Purity ≥98%

    Description: NSC59984 is a novel and potent activator of p53 with potential anticancer activity. It acts via induction of mutant p53 protein degradation and p73 activation. 

    ReferencesZhang S, et al. Cancer Res. 2015, 75(18), 3842-3852. 

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    Molecular Weight (MW)265.27
    FormulaC12H15N3O4
    CAS No.803647-40-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 53.0 mg/mL (199.8 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol:  53.0 mg/mL (199.8 mM)
    SMILESNSC59984; NSC-59984; NSC 59984; (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one


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    GeneralIn nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner.
    Animal modelNude mice bearing DLD-1 xenograft tumors
    FormulationN/A
    Dosages45 mg/kg
    Administrationi.p. injection every 5 days
    ReferencesZhang S, et al. Cancer Res. 2015, 75(18), 3842-3852.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    	NSC59984

    Effects of NSC59984 injection on tumor growth and cell death in xenograft tumors in vivo. Zhang S, et al. Cancer Res. 2015, 75(18), 3842-3852.

    	NSC59984

    p73 is required for NSC59984 to restore the p53 pathway in mutant p53-expressing tumor cells. Zhang S, et al. Cancer Res. 2015, 75(18), 3842-3852.
     


    	NSC59984

    NSC59984 induces mutant p53 degradation via MDM2-mediated ubiquitination. Zhang S, et al. Cancer Res. 2015, 75(18), 3842-3852.


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