ROCK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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ROCK

ROCK related products

Cat No.	Product Name	CAS No.	Product Description
V114421	(Rac)-NRL-1049 dihydrochloride	863638-93-1	(Rac)-BA 1049 is a racemic variant of NRL-1049 (BA-1049).
V136770	Glycerophosphoinositol 4-phosphate disodium		Glycerophosphoinositol 4-phosphate disodium is a metabolite of phospholipase A and an inhibitor of adenylate cyclase.
V2730	GSK180736A	817194-38-0	GSK180736A (GSK-180736A) is a GRK2 inhibitor thatwasdeveloped as a novel and potent Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitor whichbinds to GRK2 (G protein-coupled receptor kinase 2) with IC50of 0.77 μM; G protein-coupled receptors (GPCRs) are central to many physiological processes.
V2561	GSK269962 (GSK269962A)	850664-21-0	GSK269962 (also known as GSK269962A) is a novel, potent and selective inhibitor of ROCK (Rho-associated protein kinase) with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
V1345	GSK429286A	864082-47-3	GSK429286A (also known as RHO15;GSK 429286A;RHO-15;GSK-429286A)is a potent, orally bioactive, andselective inhibitor of ROCK1/2 with antihypertensive effects.
V2563	Kobe0065	436133-68-5	Kobe0065 (Kobe 0065) is novel and potent inhibitor of the H-Ras-cRaf1 interaction whichexhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM.
V2564	PD0166285	185039-89-8	PD0166285 (PD-0166285) is a novel and potent Wee1 and Chk1 inhibitor with anticancer activity and enzymatic activity at nanomolar concentrations (IC50s of 24 and 72 nM for WEE1 and Myt1, respectively).
V144104	Rhodblock 1a	701226-08-6	Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway.
V2562	RK-33	1070773-09-9	RK-33 is a potent and first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
V1346	RKI-1447	1342278-01-6	RKI-1447 (ROCK Inhibitor XIII; RKI 1447; RKI1447) is a potent small molecule inhibitor of ROCK1 and ROCK2 with potential antitumor activities againstbreast cancer.
V88764	ROCK-IN-10	1038549-25-5	ROCK-IN-10 (compound 50) is a potent ROCK inhibitor with IC50 values of 6 nM and 4 nM for ROCK1 and ROCK2, respectively.
V144266	ROCK-IN-11	445267-51-6	ROCK-IN-11 is a potent inhibitor of ROCK1 and ROCK2, with an IC50 ≤ 5 μM.
V144267	ROCK-IN-12		ROCK-IN-12 is a selective ROCK inhibitor.
V144264	ROCK/HDAC-IN-2		ROCK/HDAC-IN-2 is a ROCK/HDAC inhibitor with IC50 values of 0.185 µM, 0.8 µM, and 0.7 µM for HDAC6, ROCK1, and ROCK2, respectively.
V144265	ROCK2-IN-14	3115784-59-0	ROCK2-IN-14 is an orally effective selective ROCK2 inhibitor (IC50 = 4.8 nM) with 212 times greater selectivity for ROCK1 than ROCK1 (IC50 = 1.01 μM).
V2558	ZINC00881524 (ROCK inhibitor)	557782-81-7	ZINC00881524 is a novel, potent and selectiveROCK inhibitor.
V2556	SAR-020106	1184843-57-9	SAR-020106 is a potent,ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nM on isolated human enzyme.
V2951	SR-3677	1072959-67-1	SR-3677 (SR3677) is a potent and selective Rho-kinase/ROCK2 inhibitor with anticancer activity.
V2557	THZ1	1604810-83-4	THZ1 (THZ-1) is a novel, potent, selective and covalent/irreversible CDK7 inhibitor (IC50 = 3.2 nM) with anticancer activity.
V1184	Wogonin	632-85-9	Wogonin (Vogonin), a naturally occurring and pharmacologically-active flavonoid found in plants, has been reported to exhibit anticancer effects against various cancer cell types such as osteosarcoma, leukemia, breast cancer and glioma.