DHFR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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DHFR

DHFR related products

Cat No.	Product Name	CAS No.	Product Description
V71989	4′-DTMP	21253-58-7	4′-DTMP is a DHFR inhibitor (antagonist) with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R).
V112662	DHFR-IN-25	3002069-20-4	DHFR-IN-25 (compound N2) is a dihydrofolate reductase (DHFR) inhibitor.
V146723	UCP1172	1922152-04-2	UCP1172 is an antibacterial agent and dihydrofolate reductase inhibitor with IC50 values of 0.0089 μM, 0.22 μM, 0.41 μM and 0.030 μM against Staphylococcus aureus DfrB, DfrG, DfrA and DfrK, respectively.
V0849	Pyrimethamine	58-14-0	Pyrimethamine(Malocid;Khloridin;BW 50-63;NCI-C01683; BW50-63; Daraprim; NSC 3061; Tindurin; WR-297;RP-4753) is a potent dihydrofolate reductase (DHFR) inhibitor which isused as an antimalarialandantiprotozoaldrug.
V0851	Pemetrexed Disodium Hydrate	357166-30-4	Pemetrexed Disodium Hydrate (LY-231514;HSDB-7316; trade name Alimta), the hydrated disodium salt of Pemetrexed which is a synthetic pyrimidine-based antifolate, is a novel antifolate and antimetabolite anticancer drug targeting TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
V0848	Pralatrexate (racemic)	146464-95-1	Pralatrexate (PDX; trade name Folotyn), an antifolate which is structurally a folate analog, is a potent and selective inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.
V0847	Methotrexate	59-05-2	Methotrexate (MTX; alphamethopterin; amethopterin; methylaminopterin;CL-14377;NCIC04671;WR19039; NCI-C04671)is an FDA approvedantineoplastic and immunosuppressant drug that belongs to theantimetabolite and antifolate class of drugs.
V0850	Sulfameter	651-06-9	Sulfameter (Bayrena; Sulfametoxydiazine; 5-Methoxysulfadiazine; NSC-683528;I-2586;SH-613) is a novel,long-acting sulfonamide antibacterial agent used as a leprostatic agent and also is used to treat UTIs/urinary tract infections.