Mixed Lineage Kinase

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Mixed Lineage Kinase

Mixed Lineage Kinase related products

Cat No.	Product Name	CAS No.	Product Description
V2799	GNE-3511	1496581-76-0	GNE-3511 is a novel, highly potent and selective zipper kinase (e.g. DLK, MAP3K12) inhibitor with IC50 of 0.107 uM for DLK.
V76946	GW806742X hydrochloride		GW806742X HCl is an ATP mimetic and a potent MLKL inhibitor that binds to the MLKL pseudokinase domain with a Kd of 9.3 μM.
V74095	MLK-IN-1	1627729-62-7	MLK-IN-1 is a potent brain-penetrating specific MLK-3 inhibitor, compound 68 obtained from patent US20140256733A1.
V74097	MLKL-IN-2	899759-16-1	MLKL-IN-2 is an inhibitor (blocker/antagonist) of MLKL.
V80790	MLKL-IN-3	3031406-27-3	MLKL-IN-3 (compound 66) is a potent inhibitor of MLKL (mixed lineage kinase domain-like protein).
V87088	MLKL-IN-7		MLKL-IN-7 (compound 9) is a MLKL inhibitor, exhibits anti-necroptotic activity in HT-29 cells with IC50 value of 148.4 nM.
V34662	Necrosulfonamide HCl	432531-71-0	NecrosulfonamideHCl is a potent andcell-permeable MLKL (mixed lineage kinase domain-like) inhibitor.
V74096	Necrosulfonamide-d4	1795144-22-7	Necrosulfonamide-d4 is the deuterated form of Necrosulfonamide.
V146260	Topoisomerase I/II inhibitor 8	355400-87-2	Topoisomerase I/II inhibitor 8 is a dual catalytic inhibitor of topoisomerase I/II that can induce DNA damage and PARP-1 activation, which in turn activates RIPK1, RIPK3 and MLKL, ultimately triggering necrotizing apoptosis.
V147121	WJH-C19		WJH-C19 is an orally effective RIPK1 inhibitor with an IC50 value of 5.7 nM.
V2915	Necrosulfonamide	1360614-48-7	Necrosulfonamide is a potent and highly specific and potent necrosis inhibitor which blocks mixed lineage kinase domain-like protein (MLKL).