| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V2738 | (1S,3R,5R)-PIM447 dihydrochloride | 1S,3R,5R)-PIM447 dihydrochloride a potentPIMinhibitor extracted withIC50values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. | |
|
V0441 | (Z)-SMI-4a | 438190-29-5 | Z)-SMI-4a (the Z-enantiomer of SMI-4a), a novel benzylidene-thiazolidine-2, 4-dione small molecule, is a potent and selectivePim1inhibitorwith potential antineoplastic activity. |
|
V0442 | AZD1208 | 1204144-28-4 | AZD1208 is a novel, highly selective,ATP-competitiveand orally bioavailable small molecule pan-inhibitor of Pim kinase with potential antitumor activity. |
|
V2552 | CX-6258 | 1202916-90-2 | CX-6258 is a novel, potent, selective and orally bioactive pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
|
V0443 | CX-6258 HCl | 1353859-00-3 | CX-6258 HCl(known also as CX-6258 hydrochloride) is a novel, highly potent and orally bioactive pan-Pim kinase inhibitor with potential anticancer activity. |
|
V2370 | NSC 31205 | 6320-51-0 | Pim-1/2 kinase inhibitor 1 is an orally bioavailable Pim-1/2 kinase inhibitor. |
|
V74390 | Pim-1 kinase inhibitor 3 | 2801695-39-4 | Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor (antagonist) with IC50 of 35.13 nM. |
|
V74383 | Pim-1 kinase inhibitor 6 | 2928606-69-1 | Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor (antagonist) with IC50 of 0.46 μM and significant cytotoxic effect against cancer cells. |
|
V74388 | PIM-1/HDAC-IN-1 | 2897622-19-2 | PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor (antagonist) with IC50 of 343.87 nM. |
|
V2728 | PIM447 | 1210608-43-7 | PIM447 (also known as LGH447)is a novel and potent pan-PIM (proviral insertion site of Moloney murine leukemia)kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. |
|
V2737 | PIM447 dihydrochloride | 1820565-69-2 | PIM447 2HCl (also known as LGH447 dihydrochloride), thedihydrochloride salt of PIM447, is a novel and potent pan-PIM (proviral insertion site of Moloney murine leukemia)kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. |
|
V74387 | R8-T198wt | 2305815-72-7 | R8-T198wt is a cell-penetrating/penetrable, carboxy-terminal p27Kip1 peptide that displays anti-tumor effects by inhibiting Pim-1 kinase. |
|
V0440 | SGI-1776 | 1025065-69-3 | SGI-1776 is a novel, potent and ATP-competitive pan-inhibitor of the serine/threonine family of Pim kinase (an enzyme regulating cell survival) with potential antitumor activity. |
|
V144823 | SGI-1776-amide-C6-acid | 3013618-83-9 | SGI-1776-amide-C6-acid is a target protein ligand-linker conjugate containing a Pim inhibitor and a PROTAC linker that recruits E3 ligases. |
|
V2979 | TCS PIM-1 1 | 491871-58-0 | TCS PIM-1 1, also known as sc-204330, is a highly potent substituted pyridone and selective ATP-competitive inhibitor of Pim-1 kinase with IC50 of 50 nM, it displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). |
|
V3233 | TCS-PIM-1-4a (SMI-4a) | 327033-36-3 | TCS-PIM-1-4a ( (the mixture of E- and Z-enantiomers of SMI-4a) is a novel Pim inhibitor with IC50of 13 nM for Pim-1 and 2.3 μM for Pim-2. |
|
V146893 | VB1080 | VB1080 is a potent PIM inhibitor with IC50 values of 69.5, 4996, and 9.88 µM for PIM1, PIM2, and PIM3, respectively. |
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