| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V109189 | (S)-c-Kit-IN-12 | 2797973-69-2 | (S)-c-Kit-IN-12 (compound 2b) is a potent c-Kit inhibitor with IC50 values of less than 10 nM against c-Kit in four KIT mutant cell models (BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, and EX11 DEL/V654A). |
|
V3474 | AZD3229 | 2248003-60-1 | AZD3229 (AZD-3229) is a novel, potent, pan-KIT mutantinhibitor with anticancer activity. |
|
V120281 | c-Kit-IN-10 | 1123512-36-6 | c-Kit-IN-10 (compound 1) is a c-Kit inhibitor. |
|
V131853 | c-Kit-IN-15 | c-Kit-IN-15 is a c-Kit inhibitor. | |
|
V3757 | DCC-2618 HCl | Ripretinib HCl (DCC2618; DCC-2618; Qinlock), the hydrochloride salt of DCC-2618, is an orally bioactive pan KIT and PDGFRA inhibitor approved in 2020 for the treatment of adults with advanced gastrointestinal stromal tumor. | |
|
V134970 | EGFR-IN-164 | EGFR-IN-164 is a selective covalent allosteric EGFR inhibitor. | |
|
V118895 | KIT V559D/T670I Recombinant Human Active Protein Kinase | KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic progenitor cells in the bone marrow. | |
|
V141929 | Opelkibart | 2771389-44-5 | Opelkibart is a monoclonal antibody against KIT human IgG1κ. |
|
V15392 | SU14813 | 627908-92-3 | SU14813 is a novel, orally bioavailable, multi-targeted tyrosine kinase inhibitor (TKI) withIC50s of 50, 2, 4, 15 nM forVEGFR2,VEGFR1,PDGFRβandKIT, respectively. |
|
V146921 | VEGFR2-IN-84 | 861877-12-5 | VEGFR2-IN-84 is an orally active multi-target tyrosine kinase inhibitor based on a naphthalene ring skeleton. |
|
V0630 | Pexidartinib (PLX3397; Turalio; CML261; FP113) | 1029044-16-3 | Pexidartinib (formerly PLX-3397; CML-261;FP-113; trade name Turalio) is an orally bioavailable and multi-targeted RTK (receptor tyrosine kinase) inhibitor of CSF-1R, Kit, and Flt3 with potential antineoplastic activity. |
|
V0572 | Imatinib Mesylate (STI571; Gleevec; Glivec) | 220127-57-1 | Imatinib Mesylate (also known as STI571 mesylate; trade names: Gleevec or Glivec), the mesylate salt of imatinib, is an orally bioavailable,potent,multi-kinase inhibitor of v-Abl, c-Kit and PDGFR with potential antitumor activity. |
|
V0631 | Dasatinib Monohydrate (BMS354825; Sprycel) | 863127-77-9 | Dasatinib (formerly BMS-354825; trade name Sprycel), an approved anticancer drug, is an orally bioavailable and multi-targeted kinase inhibitorof Abl, Src and c-Kit with potential anticancer activity. |
|
V2886 | Avapritinib | 1703793-34-3 | Avapritinib (formerly known as BLU-285; trade name Ayvakit) is an oral, potent and selective small molecule inhibitor of PDGFRα D842V and KIT Exon 17 mutants (IC50=0.5 nM) with anticancer activity. |