PDE

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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PDE

PDE related products

Cat No.	Product Name	CAS No.	Product Description
V0787	S- (+)-Rolipram (ME-3167; SB95952; ZK-62711)	85416-73-5	S-(+)-Rolipram, theS-isomer of rolipram (ME3167;SB-95952; ZK62711), isa potent phosphodiesterase PDE4-inhibitor with potent anti-inflammatory and anti-depressant activity.
V135116	Enpp-1-IN-30		Enpp-1-IN-30 is an ENPP1 inhibitor with high oral bioavailability, and its human IC50 value is 13.1 nM.
V0783	GSK256066	801312-28-7	GSK256066 (GSK-256066; GSK 256066) is a novel, potent and selective inhibitor of PDE4B (phosphodiesterase 4B) with important biological activity (e.
V0792	Mardepodect (PF-2545920; MP-10)	898562-94-2	Mardepodect (formerly known as PF-2545920, PF2545920, MP10; MP-10) is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with antipsychotic activity.
V2648	Mardepodect HCl (PF-2545920 HCl)	2070014-78-5	Mardepodect HCl, the hydrochloric acid salt of PF-2545920 (Also known as Mardepodect,MP-10), is a novel, potent and selective PDE10A (phosphodiesterase) inhibitor with IC50 of 0.37 nM, andwith >1000-fold selectivity over the PDE.
V142262	PAT-078	1682644-84-3	PAT-078 is a type II autosecretin (ATX) inhibitor.
V142333	PDE3/4-IN-2	2857007-03-3	PDE3/4-IN-2 is a dual inhibitor of PDE3A and PDE4B1, with an IC50 of 0.13 nM for PDE3A and 50 nM for PDE4B1.
V142334	PDE3/4-IN-3	2939748-69-1	PDE3/4-IN-3 is an orally effective dual PDE3/4 inhibitor with IC50 values of 0.17 nM for PDE3A and ≤50 nM for PDE4B2.
V142632	Phosphodiesterase-IN-4		Phosphodiesterase-IN-4 is a potent inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP1).
V144433	RX-RA-69	77749-49-6	RX-RA-69 is an orally effective platelet phosphodiesterase (PDE) inhibitor with an IC50 of 1 nM.
V144915	Sildenafil chlorosulfonyl	139756-22-2	Sildenafil chlorosulfonyl is an intermediate in the synthesis of sildenafil, a phosphodiesterase 5 (PDE5) inhibitor.
V145068	SMQ-03-20		SMQ-03-20 is a highly bioavailable, selective, and potent PDE11A4 inhibitor that can cross the blood-brain barrier.
V2623	TAK-063 (Balipodect)	1238697-26-1	Balipodect (formerly also known as TAK-063) is a novel,highly potent, orally bioavailable and selective phosphodiesterase 10A (PDE10A) inhibitor with potential usefulness inthe treatment of schizophrenia.
V146830	V11294	162278-10-6	V11294 is a phosphodiesterase 4 (PDE4) inhibitor with a Ki value of 436 nM for human lung PDE4.
V4577	Udenafil	268203-93-6	Udenafil (formerly known as DA8159) isa novel and potent PDE5 inhibitor used in urology to treat erectile dysfunction.
V0793	Dyphylline	479-18-5	Dyphylline (also named as Diprophylline; Corphyllin;Lufyllin; Neothylline), a xanthine derivative with bronchodilator and vasodilator effects,is used in the treatment of respiratory disorders like cardiac dyspnea,asthma, and bronchitis.
V0780	Tadalafil (IC 351; Cialis)	171596-29-5	Tadalafil (formerly known as IC351; IC-351;trade name Cialis) is a potent, orally bioavailable, reversible and competitive small-molecule inhibitor of PDE-5 (phosphodiesterase 5) with the potential to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension.
V0796	Irsogladine	57381-26-7	Irsogladine (MN1695; MN 1695; Gaslon; MN-1695; Dicloguamine),a mucosal protective drug, is a novel and potent PDE4 inhibitor and muscarinic acetylcholine receptor binder with anti-ulceric activity.
V0782	Pimobendan	74150-27-9	Pimobendan (UD-CG115; UDCG115;Trade names Vetmedin, Acardi), a veterinary medication approvedto treat CHF-congestive heart failure in dogs, is a potent and selective inhibitor ofphosphodiesterasePDE3 with positive inotropic and vasodilator effects.
V0790	Dipyridamole ( NSC-515776; RA-8; Persantine)	58-32-2	Dipyridamole (also known as NSC515776; RA8; Persantine) is a pyrimido-pyrimidine based phosphodiesterase (PDE) inhibitor with antiplatelet properties.