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EGFR

EGFR related products

Structure Cat No. Product Name CAS No. Product Description
AZ7550甲磺酸盐 V4282 AZ7550 Mesylate 2319837-99-3 AZ7550 Mesylate (AZ-7550), the mesylate salt ofAZ 7550, is an active metabolite ofAZD-9291 (Osimertinib) by removing one of the methyl groups from the ethyl diamine side chain.
Becotatug (JMT-101) V69398 Becotatug (JMT-101) 2648260-93-7 Becotatug (JMT-101) is an IgG1 antibody targeting EGFR and can also be coupled with Afatinib and Osimertinib to form an ADC.
DBPR112 V69401 DBPR112 1226549-49-0 DBPR112 is an orally bioactive fluoropyrimidine-based EGFR inhibitor (antagonist) with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively.
DHFR-IN-4 V69381 DHFR-IN-4 2820126-49-4 DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor (antagonist) with IC50 of 123 nM.
EGFR T790M/L858R-IN-2 V77049 EGFR T790M/L858R-IN-2 EGFRT790M/L858R-IN-2 is a potent and specific EGFRT790M/L858R inhibitor (antagonist) with IC50s of 3.5 and 1290 nM for EGFRT790M/L858R and EGFR WT respectively.
EGFR-IN-15 V69414 EGFR-IN-15 2573869-16-4 EGFR-IN-15 (compound I-005) is an EGFR inhibitor (antagonist) with IC50 of 4 nM.
EGFR-IN-16 V69427 EGFR-IN-16 133550-22-8 EGFR-IN-16 (compound 3) is a potent EGFR inhibitor (antagonist) with pIC50s of 4.85 and 4.74 for EGFR and HER-2, respectively.
EGFR-IN-83 V79490 EGFR-IN-83 EGFR-IN-83 (Compound 9) is an EGFR inhibitor (IC50= 2.53 nM).
EGFR-IN-86 V79925 EGFR-IN-86 EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50= 1.5 nM) with high activity against glioblastoma.
EGFR/BRAF-IN-1 V69432 EGFR/BRAF-IN-1 2906174-89-6 EGFR/BRAF-IN-1 (compound 21) is a 2,3-dihydropyrazino[1,2-a]indole-1,4-dione analogue, a potent EGFR/BRAF inhibitor, with IC50 of BRAFV600E is 45 nM.
EGFR/CSC-IN-1 V69409 EGFR/CSC-IN-1 2820447-02-5 EGFR/CSC-IN-1 is a potential dual (bifunctional) inhibitor of EGFR (IC50 10.52 nM) and cancer stem cells (CSC) for triple-negative breast cancer research.
EGFR/HER2-IN-7 V69383 EGFR/HER2-IN-7 2820126-28-9 EGFR/HER2-IN-7 is a potent anticancer agent with high selectivity for cancer cells and specifically acts on breast cancer cells MCF-7.
EMI1 V69420 EMI1 35773-42-3 EMI1 is a potent inhibitor of the EGFR triple mutants EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S.
EMI48 V69413 EMI48 34564-13-1 EMI48 is an analogue of EMI1 and has greater potency against mutant EGFR than EMI1.
EMI56 V69410 EMI56 2414374-41-5 EMI56 is an analogue of EMI1 and has greater potency against mutant EGFR than EMI1.
JCN037 (JGK037) V69339 JCN037 (JGK037) 2305154-31-6 JCN037 (JGK037) is a potent, covalent, BBB (blood-brain barrier) permeable (penetrable) EGFR inhibitor (antagonist) with IC50s of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvIII respectively.
Oligopeptide-41 V81005 Oligopeptide-41 Oligopeptide-41 is a biologically active peptide with hair growth-promoting effects that has been reported for use as an ingredient of cosmetics.
Os30 V81015 Os30 2998928-68-8 Os30 is a potent fourth-generation EGFR inhibitor and a potent EGFRC797S-TK inhibitor (antagonist) with IC50s of 18 nM and 113 nM for EGFRDel19/T790M/C797S TK and EGFRL858R/T790M/C797S TK, respectively.
PROTAC EGFR degrader 8 V69382 PROTAC EGFR degrader 8 2925923-46-0 PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader.
Simotinib hydrochloride V69434 Simotinib hydrochloride 1538617-88-7 Simotinib HCl is a selective, specific, orally bioavailable EGFR tyrosine kinase inhibitor (TKI) (antagonist) with IC50 of 19.9 nM.
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