Topoisomerase

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Topoisomerase

Topoisomerase related products

Cat No.	Product Name	CAS No.	Product Description
V3121	(±)-10-Hydroxycamptothecin	64439-81-2	10-Hydroxycamptothecin, a naturally occuring indole alkaloid isolated from Camptotheca acuminate, is a cell-permeable and potent inhibitor of topoisomerase I.
V1421	(S)-10-Hydroxycamptothecin	19685-09-7	10-Hydroxycamptothecin (also abbreviated as 10HCPT; 10OHCPT; HCPT; 10 HCPT), the 10-hydroxylated form of camptothecin, is a natural product and topoisomerase I inhibitor with potential anticancer activity.
V1397	SN-38 (NK012)	86639-52-3	SN-38 (NK012; SN-38; NK-012; SN 38; 10-hydroxy-7-ethylcamptothecin) is the active metabolite of Irinotecan (CPT-11) which is a Topoisomerase I inhibitor approved for use as an anticancer drug.
V78289	AHr		AuM1Phe is an N-heterocyclic carbene (NHC) metal complex that blocks human topoisomerase I activity and actin polymerization.
V128723	Aminocaproyl-Val-Cit-PABC-Exatecan TFA	3029114-40-4	Aminocaproyl-Val-Cit-PABC-Exatecan TFA is a drug-linker conjugate for antibody-drug conjugates (ADCs), consisting of a cleavable linker (aminocaproyl-valine-citrate-PABC) and essanotecan (a topoisomerase I inhibitor).
V102149	Anticancer agent 217	2916406-04-5	The anticancer agent 217 (35B) is a camptothecin compound with IC50 values of 6.2 nM and 7.1 nM for MCF-7 and MDA-MB-231 cells, respectively.
V88794	Anticancer agent 218	2916406-46-5	Anticancer agent 218 (P136) is a camptothecin compound with anticancer activity.
V102140	Anticancer agent 219	2916407-63-9	Anticancer agent 219 (P139) is a camptothecin compound with anticancer activity.
V1398	Beta-Lapachone (ARQ-501)	4707-32-8	Beta-Lapachone (also known as ARQ-501; NSC 26326;ARQ501;NSC-26326) is a novel, naturally occurring, potent and selective DNA topoisomerase I inhibitor with potential antineoplastic activity.
V88523	Cholesterol hemisuccinate Tris salt	102601-49-0	Cholesterol hemisuccinate Tris salt (CHS-Tris) is often used as a substitute for cholesterol in protein crystallography.
V133892	Diospyrin	28164-57-0	Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic activity, glutathione S-transferase inhibitory activity, and topoisomerase I inhibitory activity.
V118441	DNA/TOP2A-IN-1		DNA/TOP2A-IN-1 is a dual inhibitor of DNA and TOP2A.
V135487	Exatecan analog 13	1599439-47-0	Exatecan analog 13 is an analogue of Exatecan.
V115419	GI-149893	149809-18-7	GI-149893 is a selective topoisomerase I (TopoI) inhibitor.
V1420	GSK-J1	1373422-53-7	GSKJ1 (GSK-J1; GSK-J 1; GSK-J-1) is a novel, highly selective and potent inhibitor of histone demethylase (H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A) with potential antineoplastic activity.
V137836	Ifinatamab deruxtecan	2484870-92-8	Ifinatamab deruxtecan is an antibody-drug conjugate (ADC) targeting B7-H3, consisting of a humanized anti-B7-H3 monoclonal antibody, an enzyme-cleavable peptide linker, and an Exatecan derivative (DXd).
V94309	Indotecan hydrochloride	1228035-68-4	Indolecan hydrochloride is an indenoisoquinoline derivative and a potent inhibitor of topoisomerase I.
V114941	KW-2170 hydrochloride	207862-44-0	KW-2170 hydrochloride is an alkylating agent and a topoisomerase II inhibitor.
V116415	LD2-3	3040077-52-6	LD2-3 is a topoisomerase I inhibitor.
V107055	Levofloxacin mesylate	226578-51-4	Levofloxacin mesylate is an oral antibiotic that is active against both Gram-positive and Gram-negative bacteria.