FXR

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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FXR

FXR related products

Cat No.	Product Name	CAS No.	Product Description
V107201	Chenodeoxycholic acid 3-glucuronide	58814-71-4	Chenodeoxycholic acid 3-glucuronide is a metabolite of chenodeoxycholic acid, which can activate key nuclear receptors (FXR) with an EC50 of 8 μM and an EC50 of 11 μM for FXR activation in HEK293T cells.
V104307	FXR agonist 10		FXR agonist 10 (Compound 27) is an agonist of FXR with an EC50 of 14.26 μM.
V115591	FXR agonist 13		FXR agonist 13 is a highly selective, orally effective, and potent FXR agonist (EC50 = 0.097 μM) with good hepatic microsomal metabolic stability.
V110955	FXR agonist 15	2991276-14-1	FXR agonist 15 is a selective, orally effective farnesoid X receptor (FXR) agonist with an EC50 value of 0.76 μM.
V87447	FXR agonist 3		FXR agonist 3 is an anti-NASH agent that acts by activating FXR.
V87448	FXR agonist 4	3025841-47-5	FXR agonist 4 (compound 10a) is a farnesoid X receptor (FXR) agonist with an EC50 value of 1.05 μM.
V74031	FXRagonist 5	2414008-05-0	FXR agonist 5 (compound 1) is an FXR agonist.
V29731	Gly-β-MCA	66225-78-3	Gly-β-MCA is a bile acid acting as an oral and potent farnesoid X receptor (FXR) inhibitor with the potential to be usedfor the treatment of metabolic disorders.
V1841	GW-4064	278779-30-9	GW4064 (GW-4064) is a novel, potent and selective agonist of farnesoid X receptor (FXR) (EC50 of 65 nM in CV1 cell line) with potential usefulness in the treatment of cholestatic liver disease.
V104460	LZ-007	2920000-23-1	LZ-007 LZ-007 is an agonist of farnesoid X receptor (FXR) with EC50 of 51 nM as determined by TR-FRET and EC50 of 76 nM for FXR in HepG2 cells.
V141760	Obeticholic acid-d4-1		Obeticholic acid-d4-1 is a deuterated obeticholic acid.
V145622	Tauro-obeticholic acid-d5		Tauro-obeticholic acid-d5 is deuterated tauroobeticholic acid.
V1842	Turofexorate Isopropyl (XL335)	629664-81-9	Turofexorate Isopropyl (also known as WAY-362450, Fxr 450 and XL335) is a novel, highly potent, selective and orally bioavailable FXR (farnesoid X receptor) agonist with EC50 of 4 nM, it is highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc.
V1844	Obeticholic Acid (6-ECDCA; INT-747)	459789-99-2	Obeticholic Acid (INT747; 6-ECDCA; 6-Ethylchenodeoxycholic acid; trade name Ocaliva), a novel derivative of cholic acid, is a potent,orally bioactive and selectiveagonist of farnesoid X receptor (FXR) with EC50 of 99 nM, and has anticholeretic and anti-inflammatory activities.
V3701	Tropifexor	1383816-29-2	Tropifexor (also known as LJN452) is a novel, potent and highly potent agonist of FXR (farnesoid X receptor) with an EC50 value of 0.2 nM in HTRF assay.
V1843	Lithocholic acid	434-13-9	Lithocholic acid (3α-Hydroxy-5β-cholanic acid), a secondary bile acid formed from chenodeoxycholate by bacterial action, acts as a detergent to solubilize fats for absorption and is itself absorbed.