| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
|
| Targets |
2.49 nM (EGFR), 3.95 nM (p-wtEGFR), 4.48 nM (pEGFRvⅢ)[1].
|
|---|---|
| ln Vitro |
In HK301 cells and GBM39 cells, JCN037 displays GI50 values of 329 nM and 1116 nM, respectively[1].
|
| ln Vivo |
Due to a fast hydroxylation of the fused 1,4-dioxane ring, compound 5, JCN037, shows limited oral bioavailability, indicating first pass metabolism[1]. Treatment with JCN037 (compound 5, 300 mg/kg, BID) significantly improves survival; median survival improved from 37.5 days to 55 days with 5 treatment, a 47% increase[1].
|
| Cell Assay |
Western Blot Analysis[1].
Cell Types: GBM39 and GS025 cells. Tested Concentrations: 0-3333 nM Incubation Duration: Experimental Results: Downregulated pEGFRvⅢ , p Akt, p-ERK, and p-S6 protein levels, dramatically. |
| References |
| Molecular Formula |
C16H11BRFN3O2
|
|---|---|
| Molecular Weight |
376.179846048355
|
| Exact Mass |
375.001
|
| CAS # |
2305154-31-6
|
| PubChem CID |
138513760
|
| Appearance |
Off-white to light yellow solid powder
|
| LogP |
3.9
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
6
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
23
|
| Complexity |
419
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
BrC1=CC=CC(=C1F)NC1C2=CC3=C(C=C2N=CN=1)OCCO3
|
| InChi Key |
MTLUFWWVOINWEL-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C16H11BrFN3O2/c17-10-2-1-3-11(15(10)18)21-16-9-6-13-14(23-5-4-22-13)7-12(9)19-8-20-16/h1-3,6-8H,4-5H2,(H,19,20,21)
|
| Chemical Name |
N-(3-bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 250 mg/mL (664.58 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (16.61 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6583 mL | 13.2915 mL | 26.5830 mL | |
| 5 mM | 0.5317 mL | 2.6583 mL | 5.3166 mL | |
| 10 mM | 0.2658 mL | 1.3292 mL | 2.6583 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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