| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V4690 | ACY-1083 | 1708113-43-2 | ACY-1083 is a novel, potent, selective and brain-penetrant HDAC6 inhibitor with an IC50 of 3 nM. |
|
V4565 | ARN 077 | 1373625-34-3 | ARN 077 (ARN-077) is a novel, potent and selectiveN-acylethanolamine acid amidase (NAAA)inhibitor with anIC50of 7 nM for human NAAA. |
|
V4601 | Bamirastine | 215529-47-8 | Bamirastine (also known as TAK-427),a new imidazopyridazine derivative, is a novelantihistamine compound withantiallergic effects. |
|
V4713 | BI8626 | 1875036-75-1 | BI8626 is a novel, potent and specific inhibitor of the ubiquitin ligaseHUWE1with anIC50of 0.9 μM. |
|
V4773 | CHMFL-BTK-01 | 2095280-64-9 | CHMFL-BTK-01 (compound 9) is a novel, potent, highly selective and irreversible/covalentBTK (Bruton's tyrosine kinase)inhibitor with anIC50of 7 nM. |
|
V4634 | Diflapolin | 724453-98-9 | Diflapolin is reported to be the first potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor. |
|
V4792 | FGTI-2734 | 1247018-19-4 | FGTI-2734 is a novel and potent RAS C-terminal mimetic dualfarnesyl transferase (FT)andgeranylgeranyl transferase-1 (GGT)inhibitor that thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors withIC50s of 250 nM and 520 nM forFTandGGT, respectively. |
|
V4551 | GNE-049 | 1936421-41-8 | GNE-049 is a novel, highly potent and selective CBP/p300 bromodomaininhibitor with anIC50of 1.1 nM in TR-FRET assay. |
|
V4746 | IMD-0560 | 439144-66-8 | IMD-0560 is a novel and potent IKK inhibitor which suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration. |
|
V4789 | K-Ras G12C-IN-1 | 1629265-17-3 | K-Ras G12C-IN-1 is a novel, potent and irreversible/covalent inhibitor of K-Ras protein with G12C mutation. |
|
V4785 | KRas G12C inhibitor 2 | 2206735-61-5 | KRAS G12C inhibitor 2 is a novel and potent inhibitor of KRAS. |
|
V4865 | LY-450108 | 376594-67-1 | LY450108 is a potent AMPA receptor enhancer. |
|
V4849 | LY2979165 | 1311385-32-6 | LY2979165, a novel and potent mGlu2 agonist being developed as an anti-depressant drug candidate, has potential usefulness in the treatment of bipolar disorder. |
|
V4729 | MEK-IN-1 | 870600-45-6 | MEK-IN-1 is a MEK inhibitor from patent WO2008076415A1. |
|
V4818 | Nevanimibe HCl | 133825-81-7 | Nevanimibe HCl (also known as PD-132301 hydrochloride and ATR-101 hydrochloride), the hydrochloride salt ofNevanimibe, is a novel, selective and potent acyl-coenzyme A: cholesterol O-acyltransferase 1 (ACAT1) inhibitor with anEC50of 9 nM. |
|
V5038 | NSC-305787 HCl | 53868-26-1 | NSC305787 HCl, the hydrochloride salt ofNSC305787, is a novel, potent and selectivesmall molecule inhibitor of ezrin with a Kdof 5.85 μM, it inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50of 8.3 μM, and has antitumor activity. |
|
V4639 | NVP-2 | 1263373-43-8 | NVP-2 is a potent and specific ATP-competitive cyclin-dependent kinase 9 (CDK9) probe that can inhibit CDK9/CycT activity with IC50 of 0.514 nM. |
|
V4658 | NVP-QAV-572 | 957209-68-6 | NVP-QAV-572 is a novel and potentPI3Kinhibitor (extracted from patent US7998990B2, Compound Example 8) with anIC50of 10 nM. |
|
V4983 | PF-06446846 | 1632250-49-7 | PF‑06446846 (PF06446846; PF‑6446846) is a novel and potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that inhibits the translation of PCSK9 by inducing the ribosome to stall around codon, mediated by the sequence of the nascent chain within the exit tunnel. |
|
V4966 | PI3K-IN-6 | 1842380-77-1 | PI3K-IN-6 (compound 20a in related reference: J Med Chem. |
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