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10mg | ||
25mg | ||
50mg | ||
100mg | ||
250mg |
Purity: ≥98%
IMD-0560 is a novel and potent IKK inhibitor which suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration.
ln Vitro |
IMD-0560 pretreatment prevents TNFα-induced p65 phosphorylation and IκBα degradation. Moreover, TNFα-induced transcriptional activity is suppressed by IMD-0560. TNFα-induced cell invasion is significantly inhibited by pretreatment with IMD-0560. By preventing MMP-9 expression, pretreatment with IMD-0560 reduces MMP-9 activity[1].
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ln Vivo |
In mice administered with 5 mg/kg IMD-0560, the tumor size decreases in a dose-dependent way, and in certain mice, no tumor is found. When compared to the control groups, the IMD-0560-treated groups exhibited a considerable suppression of zygoma destruction. The 5 mg/kg IMD-0560-treated group had a smaller tumor than the 3 mg/kg IMD-0560-treated group, but both treatments had a similar inhibitory impact on the elimination of zygomas[1].
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References |
[1]. Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30
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Molecular Formula |
C15H8BRF6NO2
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Molecular Weight |
428.1239
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CAS # |
439144-66-8
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SMILES |
O=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O
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InChi Key |
SVGRIJCSKWXOPA-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C15H8BrF6NO2/c16-8-2-4-12(24)9(6-8)13(25)23-11-5-7(14(17,18)19)1-3-10(11)15(20,21)22/h1-6,24H,(H,23,25)
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Chemical Name |
N-[2,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide
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Synonyms |
IMD0560; IMD 0560; IMD-0560
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
Ethanol : ~50 mg/mL (~116.79 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.84 mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear EtOH stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.84 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear EtOH stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.3358 mL | 11.6790 mL | 23.3579 mL | |
5 mM | 0.4672 mL | 2.3358 mL | 4.6716 mL | |
10 mM | 0.2336 mL | 1.1679 mL | 2.3358 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.