PI3K

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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PI3K

PI3K related products

Cat No.	Product Name	CAS No.	Product Description
V0217	MLS-2052 (GSK-3 Inhibitor IX; BIO)	667463-62-9	MLS2052 (also known as BIO, GSK3 Inhibitor IX, 6-Bromoindirubin-3-oxime) is a novel, potent,cell-permeable bis-indolo and specific inhibitor of GSK-3 (glycogen synthase kinase-3) with potential antitumor activity.
V121487	(3aS,4R,9bR)-G-1	925419-53-0	(3aS,4R,9bR)-G-1 is a highly selective G protein-coupled receptor GPR30 (GPER) agonist with a Ki value of approximately 7 nM.
V0129	TG100-115	677297-51-7	TG100-115 is a novel, potent and selective PI3Kγ/δ inhibitor with potential cardioprotecting effects.
V0142	TG100713	925705-73-3	TG100713 is a novel and potent pan-PI3K(phosphatidylinositol 3-kinase)inhibitor with potential anti-inflammatory activity.
V0153	AMG319 (ACP-319)	1608125-21-8	AMG319 (also known as ACP319) is a novel, potent, selective, orally bioavailable small molecule inhibitor of PI3Kδ (phosphoinositide-3 kinase δ)with potential anticancer activity.
V11021	AMG-511	1253573-53-3	AMG-511 is a potent and selective pan class I PI3K inhibitor exhibiting IC50 of 8, 11, 2, and 6 nM against the PI3K β, α, β, and ≤ isoforms respectively.
V129147	Antiproliferative agent-67		Antiproliferative agent-67 is a PI3K inhibitor with a selectivity index (SI) of 7.72 for breast cancer cells (MCF-7).
V0130	AS-252424	900515-16-4	AS-252424 is a novel, potent, orally bioactive and selective PI3Kγ inhibitor with potential anticancer activity.
V0134	AS-604850	648449-76-7	AS-604850 is a novel, potent, selective, and ATP-competitive inhibitor of PI3Kγ (phosphatidylinositol 3-kinase γ) with IC50 of 250 nM and aKi of 180 nM.
V0115	AS-605240	648450-29-7	AS-605240 is a novel, potent, orally bioactive andATP-competitiveinhibitor of PI3-kinase γ (PI3Kγ) with potential anti-inflammatory activity.
V69215	ATM Inhibitor-3	2769140-52-3	ATM Inhibitor -3 (Compound 34) is a potent and specific ATM inhibitor (antagonist) with IC50 of 0.71 nM.
V0124	AZD-6482 (KIN-193)	1173900-33-8	AZD6482(KIN193) is a novel, potent, selective and ATP competitive PI3Kβ (phosphatidylinositol-3-kinase) inhibitor with potential anticancer activity.
V0152	AZD8186	1627494-13-6	AZD8186 (also known as AZD) is a novel, potent and selective inhibitor of PI3Kβ (phosphatidylinositol 3-kinase β) with potential anticancer activity.
V2544	AZD8835	1620576-64-8	AZD8835 is a novel, selective, and orally bioavailable inhibitor of the class I (PI3K) catalytic subunit alpha (PIK3CA) PI3Kα and PI3Kδ with IC50s of 6.2 and 5.7 nM, respectively with potential antineoplastic activity.
V0131	BGT226 (NVP-BGT226)	1245537-68-1	BGT226 maleate (also known as NVP-BGT226 maleate) is a novel and potent dual inhibitor of class I PI3K (phosphatidylinositol 3-kinase)/mammalian target of rapamycin (mTOR) with potential anticancer activity.
V0139	CAY10505	1218777-13-9	CAY10505, the dehydroxylated form of AS-252424, is a novel,potent and selective inhibitor ofPI3Kγ (phosphoinositide 3-kinase) with a potential toimprove hypertension-associated vascular endothelial dysfunction.
V113279	CC-11	3079942-94-9	CC-11 is an orally effective small molecule drug conjugate (SMDC) that links a PI3K/mTOR inhibitor to an extracellular heat shock protein 90 (EHSP90) targeting ligand via a cleavable linker.
V0138	CH5132799	1007207-67-1	CH5132799 is a novel and potent class I PI3K (phosphoinositide 3-kinase) inhibitor with potential anticancer activity.
V2542	CZ415	1429639-50-8	CZ415 is a potent, cell-permeable (Kd app = 6.9 nM), and ATP-competitive mTOR inhibitor with high selectivity over any other kinase (IC50 = 14.5 nM IC50 for pS6RP and 14.8 nM for pAKT) and very good pharmacokinetic properties which include moderate clearance and good oral bioavailability.
V0145	CZC24832	1159824-67-5	CZC24832 is a novel, potent and highly selectiveinhibitor of PI3Kγ (phosphoinostide 3-kinase γ)with apotential for treatment for inflammatory and autoimmune diseases (e.