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MEK

MEK

MEK related products

Structure Cat No. Product Name CAS No. Product Description
(R)-PD 0325901CL V74094 (R)-PD 0325901CL 1003216-77-0 (R)-PD 0325901CL is an isomer of PD 0325901CL.
APS-2-79 V3182 APS-2-79 2002381-25-9 APS-2-79 (APS-279) is a potent antagonist of MAPK (mitogen-activated protein kinase) with antitumor activity.
APS-2-79盐酸盐 V2664 APS-2-79 HCl 2002381-31-7 APS-2-79 HCl (APS279 HCl; APS-279), the hydrochloride salt of APS-2-79, is an antagonist of MAPK (mitogen-activated protein kinase) with anticancer effects.
AZD8330 (ARRY704; ARRY424704) V0458 AZD8330 (ARRY704; ARRY424704) 869357-68-6 AZD8330 (AZD-8330; ARRY-704; ARRY-424704) is an orally bioactive and non-ATP competitive (Allosteric) MEK 1/2 inhibitor with potential anticancer activity.
BIX 02188 V0457 BIX 02188 334949-59-6 BIX02188 (BIX-02188), an indolinone analog, is a novel, highly potent and selective MEK5 inhibitor with the potential to relieve neuropathic pain.
BIX 02189 V0450 BIX 02189 1094614-85-3 BIX02189 is a novel, potent andselective inhibitor of MEK5 with important biological activity.
GDC-0623 (G-868) V0451 GDC-0623 (G-868) 1168091-68-6 GDC-0623 (G868) is a novel, potent, orally bioactive, selective and non-ATP-competitive (allosteric) inhibitor of MEK1 with potential anticancer activity.
L-783277 V116080 L-783277 791807-02-8 L-783277 (compound 4) is a MEK inhibitor (IC50 = 4 nM).
MEK-IN-6 V74092 MEK-IN-6 2845151-86-0 MEK-IN-6 (Example 69) is a MEK inhibitor.
MEK-IN-6 hydrate V74090 MEK-IN-6 hydrate 2845153-35-5 MEK-IN-6 hydrate (compound 69) is a MEK inhibitor.
MEK-IN-8 V113162 MEK-IN-8 3002056-26-7 MEK-IN-8 (compound 30) is a MEK inhibitor (IC50 < 5 nM against pMEK in A549 cells).
MEK/RAF-IN-1 V97290 MEK/RAF-IN-1 MEK/RAF-IN-1 (compound 16b) is a MEK and RAF inhibitor with IC50 values of 28, 3, and 3 nM for MEK1, BRAF, and BRAFV600E, respectively.
PD-184352 (CI-1040) V0448 PD184352 (CI1040) 212631-79-3 PD184352 (PD-184352; CI-1040),an analog of benzhydroxamate, is an orally bioactive, specific, allosteric/non-ATP competitive MEK1/2 inhibitor with potential anticancer activity.
PD318088 V0460 PD318088 391210-00-7 PD318088 (PD-318088), an analog of PD184352, is a novel, potent and non-ATP competitive (allosteric) MEK1/2 inhibitor with potential anticancer activity.
RO4987655 V3012 RO4987655 874101-00-5 PD 169316 is a novel potent, cell-permeable and specific/selective inhibitor of p38 MAPK kinase with IC50 value of 89 nM.
SHOC2-RAS PPI-IN-1 V144849 SHOC2-RAS PPI-IN-1 SHOC2-RAS PPI-IN-1 is an inhibitor of SHOC2-NRAS interaction, with an IC50 of 0.048 μM and a Kd of 0.065 μM against SHOC2.
SL-327 V0456 SL-327 305350-87-2 SL327 (SL-327) is a novel, potent and selective inhibitor for MEK1/2 with the ability to cross blood brain barrier andblock fear conditioning.
SL43 V145022 SL43 SL43 is an orally effective and potent SOS1 inhibitor with a Kd value of 0.16 μM.
TAK-733 V0459 TAK-733 1035555-63-5 TAK-733 is a novel, potent, selective andorally bioavailable allosteric (non-ATP competitive) inhibitor of MEK with potential anticancer activity.
Trametiglue V74085 Trametiglue 2666940-97-0 Trametiglue is an analogue of trametinib that targets KSR-MEK and RAF-MEK with unprecedented potency and selectivity through unique interfacial binding interactions.
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