Sirtuin

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Sirtuin

Sirtuin related products

Cat No.	Product Name	CAS No.	Product Description
V0436	AGK2	304896-28-4	AGK2 is a novel, potent, and selective inhibitor of SIRT2 (sirtuin 2, histone deacetylase) with potential anti-inflammatory activity.
V131820	Citriniorl A		Citriniorl A is a SIRT1 enhancer with an EC50 value of 5.8 μM.
V133346	DDL-218	2767324-34-3	DDL-218 is an orally effective and potent SirT1 inhibitor.
V141296	NH4-6	2375182-58-2	NH4-6 is a SIRT2 inhibitor with an IC50 value of 0.032 μM for SIRT2 and 3 μM for SIRT1.
V3140	OSS-128167	887686-02-4	OSS_128167 (formerly SIRT6-IN-1) is a novel, potent and selectiveSIRT6inhibitor withIC50 of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
V55738	Selaginellin	941269-84-7	Selaginellin is an inhibitor (blocker/antagonist) of Reactive Oxygen Species and an activator of SIRT1.
V0429	Selisistat (SEN0014196; EX 527)	49843-98-3	Selisistat (formerly SEN-0014196; EX-527) is a novel, highlypotent and selective inhibitor of SIRT1 (Sirtuin1, aNAD-dependent and class III histone deacetylase enzyme) with important biological activity.
V0439	SirReal2	709002-46-0	SirReal2 is a novel, highly potent and isoform-selective inhibitor of Sirt2 (Sirtuin 2) with potential anticancer and anti-inflammatory activity.
V106893	SIRT-IN-6	1431411-18-5	SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC50 value >50 μM.
V144973	SIRT1 activator 4	1049800-47-6	SIRT1 activator 4 is an orally effective, NAD+-independent SIRT1 activator.
V144974	Sirt1/2-IN-5	143034-06-4	Sirt1/2-IN-5 is a SIRT1/SIRT2 inhibitor with an IC50 value of 0.3 μM for human SIRT1, an IC50 value of 1.2 μM for human SIRT2, and a pIC50 value of 5.82.
V88781	SIRT2-IN-15	312275-43-7	SIRT2-IN-15 (compound 1) is a SIRT2 sirtuin and deamylase inhibitor with IC50 of 7 and 37 μM, respectively.
V94618	SIRT6 activator 2	2867630-96-2	SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties.
V144976	SIRT6 activator 3		SIRT6 activator 3 is a SIRT6 activator with an EC50 value of 5 μM.
V144979	Sirtuin modulator 8	925437-38-3	Sirtuin modulator 8 is a Sirtuin modulator that can activate Sirtuin activity.
V111099	Sirtuin-IN-1	1392810-44-4	Sirtuin-IN-1 (compound 18) is a SIRT1/2 inhibitor (IC50 values of 6.2 μM and 4.2 μM for SIRT1 and SIRT2, respectively).
V145016	SKLB-11A	433953-86-7	SKLB-11A is a selective, orally effective allosteric SIRT3 (sirtuin 3) agonist with a Kd value of 4.7 μM.
V4054	SRT1720	925434-55-5	SRT1720 (formerly known as CAY10559) is a novel and selective SIRT1 activator with an EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.
V0428	SRT1720 HCL (CAY-10559)	1001645-58-4	SRT1720 HCl (formerly known as CAY10559 HCl), the hydrochloride salt ofSRT1720, is a novel, potent and selective SIRT1(Sirtuin 1) activator with potential anticancer activity and isa promising new therapeutic agent for treating type 2 diabetes.
V0438	SRT2104 (GSK-2245840)	1093403-33-8	SRT2104 (formerly GSK-2245840; SRT2104;GSK2245840;SRT-2104) is a novel, first-in-class, brain penetrant, and highly selective small molecule activator of SIRT1 (Sirtuin 1) with potential use forneurodegenerative diseases.