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PARP

PARP

PARP related products

Structure Cat No. Product Name CAS No. Product Description
2'-Nitroflavone V124819 2'-Nitroflavone 53277-26-2 2'-Nitroflavone is a PARP1 inhibitor.
2-Methylquinazolin-4-ol (2-甲基-4(3H)-喹唑酮) V52511 2-Methylquinazolin-4-ol (2-methyl-4(3H)-quinazolone) 1769-24-0 2-Methylquinazolin-4-ol is a highly efficient and competitive poly(ADP-ribose) synthetase inhibitor with a Ki value of 1.1 μM.
2H-Indazole-7-carboxamide V124689 2H-Indazole-7-carboxamide 952479-70-8 2H-Indazole-7-carboxamide is a PARP1 ligand that can be used to synthesize PROTACs, such as PROTAC PARP1 degrader-1.
A-966492 V0313 A-966492 934162-61-5 A-966492 is a selective andorally bioavailable PARP [poly(ADP-ribose) polymerase] inhibitor with potential anticancer activity.
ADP-ribose/PARP-IN-1 V128337 ADP-ribose/PARP-IN-1 3047557-92-3 ADP-ribose/PARP-IN-1 is a coupling compound.
AG14361 V0305 AG-14361 328543-09-5 AG14361 (AG-14361) is a novel, potent and selective inhibitor of poly (ADP-ribose) polymerase-1 (PARP1) with potential anticancer activity.
Antitumor agent-214 V129190 Antitumor agent-214 1911631-77-0 Antitumor agent-214 is a chalcone analog with antitumor activity.
AZD0156 V2571 AZD0156 1821428-35-6 AZD0156 is a novel, orallybioactive, potent and selective inhibitor of ATM (ataxia telangiectasia mutated) kinase with an IC50 of 0.58 nM and with potential chemo-/radio-sensitizing and antineoplastic activities.
AZD2461 V0310 AZD2461 1174043-16-3 AZD-2461 is a novel, selective and potent inhibitor of Poly (ADP-ribose) polymerase (PARP) with potential anticancer activity.
BYK204165 V17321 BYK204165 1104546-89-5

BYK204165 is a novel, potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor with pIC50of 5.38 and 7.35 for PARP-2 and PARP-1 respectively.
CC-115 V2567 CC-115 1228013-15-7 CC-115 (CC115) isa novel and potent dual inhibitor of DNA-PK (DNA-dependent protein kinase) and mTOR (mammalian target of rapamycin) with IC50s of 13 nM and 21 nM, respectively and with potential antineoplastic activity.
CeMMEC1 V2566 CeMMEC1 440662-09-9 CeMMEC1, an N-methylisoquinolinone analog, is a novel and potent inhibitor of TAF4 with anticancer activity.
DB-008 V51295 DB-008 DB008 is a novel PARP16 inhibitor that contains an electrophilic reagent for acrylamide and has an IC50 value of 0.27 μM.
DiPT-4 V79155 DiPT-4 DiPT-4 is a TOP1/PARP1 dual (bifunctional) inhibitor that can induce a large number of DNA double-strand breaks (DSB), cell cycle arrest and apoptosis in cancer cells.
Fluorescein-NAD+ sodium V110417 Fluorescein-NAD+ sodium Fluorescein-NAD+ sodium is a radiolabeled NAD and a substrate for ADP ribosomalization.
G007LK V0307 G007-LK 1380672-07-0 G007-LK is a novel, potent and specific tankyrase (TNKS) 1/2 inhibitor with potential anticancer activity.
HYDAMTIQ V75781 HYDAMTIQ 1201832-32-7 HYDAMTIQ is a PARP-1/2 inhibitor (IC50= 29-38 nM) with anti-cancer, anti-inflammatory and ischemic protective effects.
JW 55 V2848 JW 55 664993-53-7 JW 55 is a potent and selective small molecule inhibitor of β-catenin signaling pathway, it functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2) which are regulators of the β-catenin destruction complex.
KU-0058948 hydrochloride V86184 KU-0058948 hydrochloride 2108829-86-1
LIB3S0280 V138850 LIB3S0280 LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM.
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