Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V80744 | Mephenytoin-d8 | Mephenytoin-d8 is the deuterium labelled form of mephenytoin. | |
|
V73939 | Methoxsalen-d3 (8-Methoxypsoralen-d3; Xanthotoxin-d3; 8-MOP-d3) | 80386-99-8 | Methoxsalen-d3 is the deuterium labelled form of Methoxsalen. |
|
V73658 | ML252 | 1392494-64-2 | ML252 is a selective inhibitor of potassium channels, targeting KCNQ2 (Kv7.2.IC50=69 nM). |
|
V73975 | MS-PPOH | 206052-02-0 | MS-PPOH is a potent and specific cytochrome P450 (CYP) cyclooxygenase inhibitor. |
|
V30448 | N-Nornuciferine | 4846-19-9 | N-Nornuciferine is an aporphine alkaloid found in lotus leaves and can significantly inhibit CYP2D6 activity, with IC50 and Kis of 3.76 and 2.34 μM. |
|
V73717 | Nav1.7-IN-8 | 1432913-44-4 | Nav1.7-IN-8 is a potent NaV1.7 blocker with high selectivity for the inhibition of NaV1.7 on hNaV1.1 and hNaV1.5 subtypes. |
|
V73986 | Nicotelline (Nicotellin) | 494-04-2 | Nicotelline (Nicotellin) is an alkaloid related to nicotine and a weak inhibitor of human cDNA expression of cytochrome P-450 2A6 (CYP2A6). |
|
V70367 | NP10679 | 2914889-88-4 | NP10679 is a selective, pH-dependent GluN2B subunit-specific N-methyl-D-aspartate (NMDA) receptor blocker/inhibitor (antagonist) with high oral bioavailability (F) and good brain penetration. |
|
V26795 | NVP-VID-400 | 174262-13-6 | SDZ285428 is a CYP51 inhibitor. |
|
V1886 | Oleuropein | 32619-42-4 | Oleuropein is a naturally occuring antioxidant polyphenol isolated from olive leaf. |
|
V73971 | ONT-993 (AR 00440993) | 937263-81-5 | ONT-993 is an aliphatic hydroxylated metabolite. |
|
V73936 | Peucedanol | 46992-81-8 | Peucedanol is a noncompetitive inhibitor of CYP3A4 with a Ki of 4.07 μM, and a competitive inhibitor of CYP1A2 and CYP2D6 with Kis of 3.39 μM and 6.77 μM respectively. |
|
V70043 | Phenyltoloxamine (Bistrimin; Histionex) | 92-12-6 | Phenyltoloxamine (Bistrimin) is an antihistamine with sedative and analgesic properties. |
|
V3958 | Pradefovir mesylate (Remofovir) | 625095-61-6 | Pradefovir mesylate(formerly known as Remofovir mesylate, ICN-2001-3 mesylate, MB-06866 mesylate, MB-6866 mesylate, ICN-20013 mesylate) is an RTI (reverse transcriptase) inhibitor that has thepotential for thetreatment of chronic HBV infection. |
|
V73966 | Resorufin methyl ether (Methoxyresorufin) | 5725-89-3 | Resorufin methyl ether (Methoxyresorufin) is a fluorescent substrate of cytochrome P450 and a specific substrate of CYP1A2 in rodents. |
|
V40510 | Rhapontigenin | 500-65-2 | Rhapontigenin is a novel and potent analog of resveratrol with multipul bioactivities such as antifungal, anticancer, antioxidant and antibacterial activities. |
|
V8139 | Schizandrin A | 61281-38-7 | Schisandrin A inhibits CYP3A activity with IC50 and Ki of 6.60 μM and 5.83 μM, respectively. |
|
V73953 | SOS1-IN-16 | 2930763-85-0 | SOS1-IN-16 (Comp 54) is a selective inhibitor of < b>SOS1 with IC50 of 7.2 nM. |
|
V15078 | Soticlestat | 1429505-03-2 | Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, orally bioactive cholesterol 24-hydroxylase (CH24H) inhibitor. |
|
V73932 | Stiripentol-d9 (Stiripentol-d9) | 1185239-64-8 | Stiripentol-d9 is the deuterium labelled form of Stiripentol. |
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