Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. The archetypal member of the Ras superfamily of proteins, which controls a variety of cell behaviors and is connected in three dimensions, is called Ras. Incoming signals cause Ras to become "switched on," which in turn causes other proteins to become "switched on," which in turn activates genes related to cell division, growth, and survival. Ras proteins that are permanently activated can therefore be produced as a result of mutations in the ras gene.Even in the absence of incoming signals, this can result in unwanted and excessive signaling within the cell. Overactive Ras signaling can eventually result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the three Ras genes (HRAS, KRAS, and NRAS); Ras inhibitors are being researched as a potential treatment for cancer and other disorders where Ras overexpression occurs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V62605 | (S)-CCG-1423 | 2319939-24-5 | (S)-CCG-1423 is an inhibitor (blocker/antagonist) of Rho signaling and blocks the nuclear import of MRTF-A. |
|
V2237 | 4-(1,3-Benzothiazol-2-ylsulfanyl)-3-chloroaniline | 300809-71-6 | KRAS inhibitor-9 is a potent KRAS inhibitor (Kd=92 μM), preventing the formation of GTP-KRAS and the downstream activation of KRAS. |
|
V74717 | 8-CPT-2Me-cAMP sodium | 634207-53-7 | 8-CPT-2Me-cAMP sodium is a selective agonist of exchange proteins activated by cAMP (Epac), a cAMP-sensitive guanine nucleotide exchange factor (GEF) of the small GTPases Rap1 and Rap2. |
|
V34672 | Adagrasib (MRTX849) | 2326521-71-3 | Adagrasib (MRTX-849; Krazati) is a newly approved, selective, orally bioavailable and covalent / irreversible inhibitor of KRAS G12C with IC50s ranging between 10 and 973 nM in the 2D format and between 0.2 and 1042 nM in the 3D format. |
|
V74720 | APS6-45 | 2188236-41-9 | APS6-45 is an orally bioactive tumor calibration inhibitor (TCI). |
|
V4764 | ARS-1323 | 1698024-73-5 | ARS-1323 (ARS1323) is the racemic mixture of ARS-1620, which is a novel and potent inhibitor of mutant K-ras G12C with anticancer activity. |
|
V3974 | ARS-1620 | 1698055-85-4 | ARS-1620 is a novel, potent, orally bioavailable and covalent inhibitor ofKRASG12C with antitumor activity. |
|
V32351 | ARS-1630 | 1698055-86-5 | ARS-1630 is a less active isomer of ARS-1620, which is a novel and potent inhibitor of mutant K-ras G12C found in patent WO 2015054572 A1. |
|
V4185 | BAY-293 | 2244904-70-7 | BAY-293 (BAY293) is a novel, potent, cell-active small-molecule SOS1 inhibitor with anticancer activity. |
|
V74704 | BI-2493 | 2937344-16-4 | BI-2493 is a structural analog of BI-2865 and a selective pan-KRAS inhibitor. |
|
V31508 | BI-3406 (SOS1-IN-2) | 2230836-55-0 | BI-3406 (BI3406; SOS1-IN-2) is a novel, orally bioactive, and selective inhibitor of Son of Sevenless 1 (SOS1) with anticancer activity. |
|
V3118 | CCG-203971 | 1443437-74-8 | CCG-203971 is a novel, 2nd generation small-molecule inhibitor of the Rho/MRTF/SRF [RhoA/myocardin-related transcription factor A (MRTF-A)] pathway with an IC50 value of 0.64 μM for SRE. |
|
V2441 | CID 44216842 | 1222513-26-9 | CID44216842 (Cdc42-IN-1) is a potent and specific Cdc42 inhibitor. |
|
V74707 | G12Si-1 | 2946593-42-4 | G12Si-1 is a selective covalent inhibitor of K-Ras(G12S) that can inhibit the transmission of K-Ras(G12S) oncogenic signals. |
|
V74726 | G12Si-2 | 2946593-43-5 | G12Si-2, an analog of G12Si-1, serves as a negative control (NC). |
|
V74723 | GGTI-286 | 171744-11-9 | GGTI-286 is a potent cell-permeable (penetrable) GGTase I inhibitor (IC50 is 2 μM). |
|
V12042 | GGTI-298 free base | 180977-44-0 | GGTI-298 (GGTI298) is a potent geranylgeranyltransferase-I (GGTase-I) inhibitor with potential anticancer actrivity. |
|
V74733 | Glecirasib (JAB-21822; KRAS G12C inhibitor 36) | 2657613-87-9 | Glecirasib (KRAS G12C inhibitor 36) is a potent KRAS G12C inhibitor. |
|
V74730 | ISIS 2503 | 149957-14-2 | ISIS-2503 is an antisense oligonucleotide that can inhibit Ha-Ras expression. |
|
V2420 | K-Ras inhibitor 6 | 2060530-16-5 | K-Ras (G12C) inhibitor 6 is a novel, potent, allosteric, irreversible,/covalent cysteine-reactive small molecule KRAS G12C inhibitor with anticancer activity. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
