Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73978 | Tabimorelin hemifumarate (NN703 hemifumarate) | 242143-80-2 | Tabimorelin (NN703) hemifumarate is an orally bioavailable growth hormone (GH) secretagogue. |
|
V9917 | Talarozole R-enantiomer | 870093-23-5 | Talarozole R-enantiomer, formerly known as R115866, is a novel, potent and orally bioavailable CYP26 inhibitor under development for the treatment of acne, psoriasis and other keratinization disorders. |
|
V73954 | Thermopsoside | 19993-32-9 | Thermopsoside is a flavonoid analogue extracted from Aspalathus linearis. |
|
V73974 | Ticlopidine (Ticlopidine; PCR 5332) | 55142-85-3 | Ticlopidine (PCR 5332) is an antithrombotic precursor that works as a noncompetitive allosteric CD39 inhibitor (antagonist) with IC50 of 81.7 μM. |
|
V4049 | TMS | 24144-92-1 | TMS (Tetramethoxystilbene), an analogue of resveratrol, is a potent and selective CYP1B1 inhibitor with an IC50 of 6 nM. |
|
V73982 | TP0472993 | 2126874-77-7 | CYP4A11/CYP4F2-IN-2 is a potent and orally bioactive dual (bifunctional) inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2 with IC50s of 140 nM and 40 nM, respectively. |
|
V71509 | Verapamil EP Impurity C hydrochloride (NSC-609249 hydrochloride) | 51012-67-0 | NSC-609249 HCl is an impurity in verapamil. |
|
V71486 | Verapamil-d3-1 hydrochloride ((±)-Verapamil-d3-1 hydrochloride; CP-16533-1-d3-1 hydrochloride) | 2714485-49-9 | Verapamil-d3-1 ( HCl) is the deuterium labelled form of Verapamil HCl. |
|
V73933 | Vildagliptin carboxylic acid metabolite TFA (Vildagliptin carboxylic acid metabolite TFA) | 565453-41-0 | Vildagliptin carboxylic acid metabolite (M20.7) TFA is a potent inhibitor of P450 enzyme activity. |
|
V73945 | VT-1598 tosylate | 2089321-00-4 | VT-1598 tosylate is an orally bioactive, selective fungal inhibitor targeting CYP51. |
|
V73934 | β-Amyrenonol (11-Oxo-β-amyrin) | 38242-02-3 | β-Amyrenonol (11-Oxo-β-amyrin) is an olea-type triterpene from licorice root and the precursor of glycyrrhetinic acid. |
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