Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments.In humans, there are 45 kinesin proteins spread across 14 different subclasses of the kinesin motor protein family. It has been established that many of these proteins—or their orthologues—have crucial roles to play in both the mitotic and meiotic cell cycles. Based on where their motor domains are located, kinesins can also be divided into three groups: internal, C-terminal, and N-terminal kinesins. Traditional kinesin moves in a coordinated, hand-over-hand manner along a microtubule protofilament, acting as a dimer.
Kinesins play critical roles in the progression of the cell cycle, cytokinesis, spindle formation, microtubule dynamics, and chromosome segregation. Kinesins typically play roles in diseases involving pathogen transport, pathogen transport defects, or cell division.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V28939 | (R)-Filanesib | 885060-08-2 | R)-Filanesib, theR-enantiomer of ARRY-520,is a novel and potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM) with anticancer activity. |
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V54364 | (S)-Monastrol ((+)-Monastrol) | 254753-54-3 | (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic motor protein Eg5 and has antiproliferation effects on a variety of cancer cell lines. |
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V2993 | Dimethylenastron | 863774-58-7 | Dimethylenastron, a quinazoline-thione analog, isa potent, cell-permeable, specific, and reversiblemitotic kinesin 5 (Eg5) inhibitor with IC50 of 200 nM. |
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V79249 | Eg5-IN-1 | Eg5-IN-1 (compound 6c) is a potent inhibitor of the kinesin family motor protein (Eg5) with IC50 of 1.97 µM. | |
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V20498 | EMD534085 | 858668-07-2 | EMD534085 is a potent and specific inhibitor of mitotic kinesin-5 with IC50 of 8 nM. |
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V4726 | Filanesib (ARRY520) | 885060-09-3 | Filanesib (formerly also known as ARRY-520) is a novel, potent and synthetic small molecule inhibitor of kinesin spindle protein (KSP) with anticancer activity. |
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V2906 | K858 | 72926-24-0 | K-858 is a novel, potent and ATP-uncompetitive inhibitor of mitotic kinesin Eg5 that has potential antitumor activity. |
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V4905 | Litronesib | 910634-41-2 | Litronesib (formerly also known as LY2523355; LY-2523355; KF-8961) is a novel, potent and selective inhibitor of the kinesin-related motor protein Eg5 with potential anticancer activity. |
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V16230 | MK-0731 | 845256-65-7 | MK-0731 (MK0731; MK 0731) is a potent kinesin spindle protein (KSP) inhibitor with potential anticancer activity. |
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V2718 | Monastrol | 329689-23-8 | Monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cell lines. |
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V75810 | PF-2771 | 2070009-55-9 | PF-2771 is a selective centromere protein E (CENP-E) inhibitor (antagonist) with IC50 of 16.1 nM and anti-tumor activity. |
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V54365 | PVZB1194 | 1141768-04-8 | PVZB1194 is a biphenyl-type inhibitor of the kinase spindle protein Eg5 or KIF11. |
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V54366 | solidagonic acid | 19941-91-4 | Solidagonic acid inhibits HSET motor activity by promoting the transition of abnormal unipolar spindles to bipolar spindles. |
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