Myosins are mechanoenzymes that interact with actin filaments and hydrolyse ATP to generate movement and force.This enables myosins to generate tension on actin filaments, which in turn allows them to walk along these filaments and propel the sliding of actin filaments. Myosins are able to control the cytoskeleton's dynamics and structure, which has an impact on how cells are transported and localized. According to their respective motor domains, the various myosins are divided into classes. Humans have 40 myosin genes, which are divided into 13 classes (I, II, III, V, VI, VII, IX, X, XV, XVI, XVIII, XIX, and XXXV) and represent the 35 known classes of myosin.
Muscle contraction, intracellular trafficking, cell division, motility, actin cytoskeletal organization, and cell signaling are just a few of the critical processes that myosins participate in. Deafness, hypertrophic cardiomyopathy, Usher syndrome, Griscelli syndrome, and cancer have all been linked to myosin dysfunction.
In order to perform its role in cytoskeleton contraction and tight junction regulation, the myosin light chain needs to be activated by the enzyme myosin light chain kinase (MLCK). In the majority of cells, MLCK functions as a signal transducer for MLC phosphorylation in response to Ca2+ binding to calmodulin associated with MLCK. Muscle contraction, cell migration, and endo/exocytic processes all benefit from MLCK-mediated MLC phosphorylation and actomyosin contractility, which is also known for playing a crucial part in signaling endothelial cell-cell adhesion and barrier function.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75828 | 16-38-Thymosin β4 (cattle) | 113318-05-1 | 16-38-Thymosin β4 (cattle) is a high-affinity Ca2+-independent MLCK activator. |
|
V77332 | 16-38-Thymosin β4 (cattle) (TFA) | 16-38-Thymosin β4 (cattle) TFA is a high-affinity Ca2+-independent MLCK activator. | |
|
V56060 | ATM-3507 trihydrochloride | 2438679-30-0 | ATM-3507 tri HCl is a potent inhibitor of tropomyosin, with IC50 of approximately 3.83-6.84 μM in human melanoma cell lines. |
|
V34749 | Blebbistatin | 674289-55-5 | Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor that promotes directional migration of corneal endothelial cells and accelerates wound healing with better preservation of cell junction integrity and barrier function. |
|
V17176 | BTS | 1576-37-0 | BTS is a novel and potent inhibitor of ATPase activity of skeletal muscle myosin II subfragment 1 (S1),specifically theCa2+-stimulated myosin S1 ATPase (IC50 = 5 μM). |
|
V51925 | JB002 | 30408-07-2 | JB002 is a myosin II inhibitor (antagonist) with IC50 ≤10 μM. |
|
V76866 | JB061 | JB061 is a non-muscle myosin inhibitor (antagonist) with IC50s of 4.4 μM (cardiac myosin), 9.1 μM (skeletal muscle myosin), and >100 μM (smooth muscle myosin II). | |
|
V51924 | JB062 | 2417988-00-0 | JB062 is a nonmuscle myosin inhibitor (antagonist) with IC50s of 1.6, 5.4 and >100 μM for skeletal muscle myosin, cardiac myosin and smooth muscle myosin II, respectively. |
|
V33894 | ML-7 hydrochloride hydrate | 110448-33-4 | ML-7 (ML7)hydrochloride hydrateis a naphthalene sulphonamide-based MLCK/Myosin light chain kinase inhibitor with anticancer activity. |
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V41175 | MPH-220 | 2649776-79-2 | MPH-220 is a selective, orally bioactive skeletal muscle myosin-2 inhibitor. |
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V56061 | MT-134 | 2968308-52-1 | MT-134 is a SkMII-specific inhibitor (antagonist) with good exposure in muscle. |
|
V75829 | Myosin Light Chain Kinase Substrate (smooth muscle) | 119386-41-3 | Myosin Light Chain Kinase Substrate (smooth muscle) is a synthetic peptide substrate for smooth muscle myosin light chain kinase (MLCK). |
|
V35021 | Myosin V-IN-1 | 1259177-59-7 | Myosin V-IN-1 (compound 8) is a potent and specific Myosin V inhibitor (antagonist) with Ki of 6 μM. |
|
V0063 | Omecamtiv mecarbil (CK1827452) | 873697-71-3 | Omecamtiv mecarbil (also known as CK-1827452) is a specific/selective cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. |
|
V79889 | Omecamtiv mecarbil-d8 (CK-1827452-d8) | Omecamtiv mecarbil-d8 is the deuterium labelled form of Omecamtiv mecarbil. | |
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V56062 | Para-aminoblebbistatin | 2097734-03-5 | Para-aminoblebbistatin is a water-soluble, non-fluorescent and photostable C15 amino-substituted blebbistatin analogue; inhibits various myosin II (myosin II) isoforms in vitro and in vivo. |
|
V52980 | Sevasemten | 2417395-15-2 | Sevasemten is an allosteric inhibitor of skeletal muscle myosin. |
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